{"id":"W3105533748","doi":"10.1139/cjpp-2020-0373","title":"Metformin alleviates hydrogen peroxide–induced inflammation and oxidative stress via inhibiting P2X7R signaling in spinal cord tissue cells neurons","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Oxidative stress; Neuroprotection; Metformin; Inflammation; Pharmacology; Purinergic receptor; Gene knockdown; Hydrogen peroxide; Medicine; Chemistry; Receptor; Endocrinology; Internal medicine; Diabetes mellitus; Apoptosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705736,0.0005050742,0.0006237568,0.0003333465,0.0002593684,0.0002972372,0.0002948958,0.0004700616,0.001209535],"category_scores_gemma":[0.00009847862,0.0001549462,0.0004654899,0.0001943782,0.0002407983,0.0002945437,0.0002343875,0.0009705714,0.0001777687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002168128,"about_ca_system_score_gemma":0.0004399777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009969249,"about_ca_topic_score_gemma":0.002259615,"domain_scores_codex":[0.9998796,0.00001618343,0.00001828369,0.0000156328,0.00003061795,0.00003970897],"domain_scores_gemma":[0.9999501,0.000004388779,0.00001877629,0.000003577541,0.000007837817,0.00001522349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000801329,0.000198271,0.0002476362,0.0003137457,0.00003526079,0.0001742045,0.00002678969,0.000146735,0.993414,0.0001074141,0.0001840011,0.004350599],"study_design_scores_gemma":[0.0002042021,0.003058678,0.01231486,0.00004718408,0.0001187885,0.0002380557,0.0001206359,0.001359143,0.9790813,0.0001504295,0.003289501,0.00001718107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913982,0.004911259,0.001626455,0.0002656471,0.0001382034,0.00006297516,0.0003253631,0.00007867286,0.001193337],"genre_scores_gemma":[0.9871457,0.006509993,0.002441155,0.0002278792,0.00004446028,0.0001570157,0.0004667156,0.00001307804,0.002993983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209535,"threshold_uncertainty_score":0.004046261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839622570805563,"score_gpt":0.2714553663668127,"score_spread":0.253059140658757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}