{"id":"W3105626811","doi":"10.3390/ijms21228747","title":"Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter","year":2020,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"University of Ottawa; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada; National Institutes of Health; National Science Foundation","keywords":"Missense mutation; Sterol; ATP-binding cassette transporter; Biology; Transmembrane protein; Allosteric regulation; Transmembrane domain; Loss function; Cell biology; Biochemistry; Transporter; Mutation; Cholesterol; Phenotype; Amino acid; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007005,0.0002034662,0.0001465774,0.00009961968,0.0001040377,0.0001957695,0.0001736271,0.0002942698,0.0007348887],"category_scores_gemma":[0.0001622624,0.00008052113,0.0001299247,0.00006729883,0.0003578441,0.0001323294,0.0002277228,0.0002316069,0.0003385439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270265,"about_ca_system_score_gemma":0.000118303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005816788,"about_ca_topic_score_gemma":0.0005884288,"domain_scores_codex":[0.999903,0.0000230009,0.00001024665,0.00002017863,0.00002831278,0.00001528295],"domain_scores_gemma":[0.9999415,0.00001114071,0.00001857191,0.000009542448,0.000007849194,0.00001135299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003774893,0.000003462585,0.0003179769,0.000007807373,0.00000136471,0.00006117587,0.000008684248,0.00003318875,0.9989932,0.000121207,0.00001347751,0.000400769],"study_design_scores_gemma":[0.00002219662,0.00006820135,0.005833543,0.000003768831,0.00001081743,0.0004197689,0.00004307633,0.003337508,0.9887241,0.0001727374,0.001358365,0.000005854496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977022,0.0002668072,0.001396033,0.00009578203,0.00001045666,0.000005676925,0.00004535513,0.00004617648,0.0004315179],"genre_scores_gemma":[0.9990414,0.00006486629,0.0005787093,0.00001841169,0.000002529017,0.000003035978,0.00003735231,0.000005969904,0.0002477138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007348887,"threshold_uncertainty_score":0.002458453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02354434702878956,"score_gpt":0.288421508896573,"score_spread":0.2648771618677834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}