{"id":"W3105631168","doi":"10.1016/j.semcancer.2020.10.013","title":"The genomic landscape of pediatric acute lymphoblastic leukemia and precision medicine opportunities","year":2020,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Disease; Myeloid leukemia; Pediatrics; Childhood cancer; Clinical trial; Minimal residual disease; Cancer; Intensive care medicine; Leukemia; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001892252,0.0006463074,0.001389854,0.002005249,0.0002595596,0.001642157,0.0009475445,0.00152305,0.003762414],"category_scores_gemma":[0.003291129,0.0002456586,0.0006362136,0.002279092,0.001209162,0.002270071,0.001072383,0.00269517,0.0009626449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001435078,"about_ca_system_score_gemma":0.00253171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001653455,"about_ca_topic_score_gemma":0.003039255,"domain_scores_codex":[0.9995745,0.0001534356,0.00003866653,0.00006923809,0.0001221018,0.00004209768],"domain_scores_gemma":[0.9978059,0.00164874,0.0001191446,0.00004953063,0.0002841741,0.00009249958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008653702,0.00003492199,0.0004525088,0.009400593,0.0001327433,0.0002784353,0.00009627542,0.0006382017,0.0007554226,0.02158032,0.05902778,0.9075163],"study_design_scores_gemma":[0.00002554341,0.00005605272,0.0008786034,0.006167199,0.0001360713,0.000924773,0.0001389298,0.0001460873,0.0002056933,0.01612831,0.9751682,0.00002454212],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004693077,0.997243,0.0001282208,0.001827886,0.0002793126,0.000001463659,0.00001477529,0.000005759714,0.0004527187],"genre_scores_gemma":[0.0007657131,0.9969645,0.0002296601,0.001205665,0.0005721684,0.000003689333,0.00003108536,0.000001333654,0.0002261658],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003762414,"threshold_uncertainty_score":0.01258653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06395015557762328,"score_gpt":0.3743114781010434,"score_spread":0.3103613225234201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}