{"id":"W3105704521","doi":"10.1101/258673","title":"Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone system","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"ALS Society of Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Ministry of Science, Technology and Space; Israel Science Foundation; Alzheimer's Society","keywords":"Neurodegeneration; Chaperone (clinical); Hsp90; Biology; Hsp70; Cell biology; Heat shock protein; Hippocampal formation; Genetics; Neuroscience; Gene; Medicine; Disease; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008777737,0.0002128815,0.0001747873,0.0002245257,0.00008962915,0.000187413,0.0001127807,0.000117495,0.001078534],"category_scores_gemma":[0.00006115774,0.0000671044,0.0001498435,0.0001325275,0.000121092,0.0001484978,0.0001705996,0.0003016143,0.0002227538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001947818,"about_ca_system_score_gemma":0.0001025135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003551953,"about_ca_topic_score_gemma":0.0003436134,"domain_scores_codex":[0.9999629,0.000003368501,0.000003305986,0.000009512731,0.000007896513,0.00001297433],"domain_scores_gemma":[0.9999579,0.000002080852,0.00001449536,0.000004782689,0.000006824945,0.00001387437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001089679,0.00001017528,0.0007908294,0.00002845265,0.000006742209,0.00004969206,0.00001172508,0.00006603621,0.9970392,0.00005350468,0.00006981967,0.001764754],"study_design_scores_gemma":[0.000007825453,0.0001736362,0.04637631,0.000009712481,0.00003365141,0.0003781036,0.00005245078,0.001156676,0.9500809,0.0001425362,0.001581903,0.000006307039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961073,0.001575161,0.001042293,0.00004766129,0.00001214182,0.00000630702,0.0005533551,0.00006958413,0.0005860776],"genre_scores_gemma":[0.9977131,0.0004987062,0.0004586886,0.00001792315,0.00000383885,0.000007185088,0.0004967751,0.000009055419,0.0007948993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078534,"threshold_uncertainty_score":0.003608108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009859695940534116,"score_gpt":0.2356542213796337,"score_spread":0.2257945254390996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}