{"id":"W3105812043","doi":"10.1016/s0140-6736(20)32292-3","title":"Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial","year":2020,"lang":"en","type":"article","venue":"The Lancet","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":324,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Dalhousie University; University of Alberta; Queen Elizabeth II Health Sciences Centre; Institute of Cancer Research; University of Calgary","funders":"Cancer Research UK","keywords":"Bortezomib; Dexamethasone; Medicine; Multiple myeloma; Proteasome inhibitor; Clinical endpoint; Internal medicine; Population; Clinical trial; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002372856,0.002815036,0.003990802,0.0005578897,0.0005408969,0.001502843,0.001251973,0.002827498,0.01105037],"category_scores_gemma":[0.002255514,0.0009991523,0.003289279,0.0005059507,0.001922734,0.001862206,0.0007216213,0.004703573,0.001731914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001229031,"about_ca_system_score_gemma":0.001194616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002036768,"about_ca_topic_score_gemma":0.003854248,"domain_scores_codex":[0.9991373,0.000468984,0.00004152557,0.0001711732,0.00005059982,0.0001303355],"domain_scores_gemma":[0.9986057,0.0005219789,0.0002682032,0.00009363046,0.00005515486,0.0004554515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9915616,0.001836411,0.0001569456,0.0002520138,0.0004732462,0.00001574497,0.00002973601,0.0001443897,0.0007171061,0.00005517123,0.0003725317,0.004385014],"study_design_scores_gemma":[0.9807327,0.0183042,0.0003795045,0.00001475551,0.0001373611,0.00001018062,0.00001276456,0.0001019402,0.00005767684,0.00007609946,0.0001653889,0.000007437728],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791917,0.008899195,0.0007682894,0.002220703,0.001555494,0.003142067,0.001644026,0.0002001248,0.002378394],"genre_scores_gemma":[0.978912,0.004477125,0.001774844,0.002313095,0.0009067254,0.00379517,0.001385276,0.00005158916,0.006384208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01105037,"threshold_uncertainty_score":0.03696716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1084690263159896,"score_gpt":0.353852140548447,"score_spread":0.2453831142324574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}