{"id":"W3105819471","doi":"10.1021/acs.jpclett.0c02327","title":"Phosphorylation-Dependent Conformations of the Disordered Carboxyl-Terminus Domain in the Epidermal Growth Factor Receptor","year":2020,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry Letters","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Richard and Susan Smith Family Foundation; National Cancer Institute; Arnold and Mabel Beckman Foundation; Alfred P. Sloan Foundation","keywords":"Autophosphorylation; Phosphorylation; Epidermal growth factor receptor; Biophysics; Tyrosine; Epidermal growth factor; Chemistry; Docking (animal); Tyrosine phosphorylation; Receptor tyrosine kinase; Cell biology; Tyrosine kinase; Protein kinase domain; Signal transduction; Receptor; Biochemistry; Biology; Protein kinase A; Mutant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009684527,0.0001694432,0.0001636934,0.0001225456,0.0003636164,0.0002850702,0.0003246246,0.0002081491,0.0010367],"category_scores_gemma":[0.0002191044,0.0001636512,0.0001848649,0.00009890323,0.0005165592,0.0005044371,0.0001766331,0.0004071566,0.00006996912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005046812,"about_ca_system_score_gemma":0.00035739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003341595,"about_ca_topic_score_gemma":0.003646716,"domain_scores_codex":[0.9999644,0.000003917618,0.000001541437,0.000008514517,0.000007333186,0.00001429317],"domain_scores_gemma":[0.9999368,0.00002224285,0.00001232455,0.000006082348,0.000006047615,0.00001648605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001429483,0.0006077755,0.01076582,0.0002865017,0.0001632375,0.001082205,0.0006024921,0.5959579,0.3641371,0.01515873,0.00144552,0.008363243],"study_design_scores_gemma":[0.0001952713,0.0003425413,0.009649514,0.00001332654,0.00004019619,0.000072355,0.0002539324,0.9469761,0.03898432,0.002754525,0.0006665121,0.00005134414],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986396,0.00005789507,0.0007120326,0.00002904837,0.000004930814,0.00000368678,0.00003297912,0.00001912117,0.0005006663],"genre_scores_gemma":[0.9992435,0.00006470374,0.0004612787,0.00001217254,0.000001295379,0.000004517172,0.00007766885,0.000007892676,0.0001270165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003341595,"threshold_uncertainty_score":0.006644249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196469788290543,"score_gpt":0.285126677865277,"score_spread":0.2631619799823715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}