{"id":"W3105826467","doi":"10.1136/jitc-2020-sitc2020.0075","title":"75 Generalizability of potential biomarkers of response to CTLA-4 and PD-1 blockade therapy in cancer","year":2020,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Generalizability theory; Blockade; CTLA-4; Cancer; Cancer therapy; Medicine; Oncology; Internal medicine; Immunology; Immune system; Mathematics; T cell; Receptor; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02935154,0.0004311512,0.0007298687,0.002370466,0.0004052526,0.002057728,0.0006368294,0.0006724089,0.003031672],"category_scores_gemma":[0.05141931,0.0002891159,0.002254179,0.002612528,0.001286056,0.0008056728,0.00165094,0.000708657,0.0005630087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006899001,"about_ca_system_score_gemma":0.0007352091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002664439,"about_ca_topic_score_gemma":0.002181778,"domain_scores_codex":[0.9857486,0.006568808,0.001585796,0.003940146,0.001693218,0.0004634317],"domain_scores_gemma":[0.9496941,0.03656404,0.003921334,0.007494854,0.00196833,0.000357366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002471807,0.0001080601,0.8959882,0.0005385719,0.004830839,0.0001922665,0.0004924669,0.01199534,0.01107481,0.0008065961,0.002628065,0.06887301],"study_design_scores_gemma":[0.0001425392,0.0009074978,0.9615269,0.0001063976,0.001722824,0.0004237027,0.0004063052,0.01665614,0.005299037,0.004729852,0.008020425,0.00005838922],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330944,0.003799109,0.04050956,0.001191499,0.000146138,0.0003540689,0.01523941,0.0007209001,0.004944867],"genre_scores_gemma":[0.9884659,0.0001836304,0.004111835,0.000434553,0.00006407995,0.0001849499,0.00615595,0.0001185601,0.0002804912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02935154,"threshold_uncertainty_score":0.1552277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02573454979681641,"score_gpt":0.2777691241262219,"score_spread":0.2520345743294055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}