{"id":"W3105835028","doi":"10.1158/2326-6066.cir-20-0138","title":"A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell–Mediated Antitumor Responses in Human B-cell Malignancies","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Academisch Medisch Centrum; Vrije Universiteit Amsterdam","keywords":"CD40; Cancer research; T cell; Chronic lymphocytic leukemia; B cell; Jurkat cells; Antibody; Cytotoxic T cell; Immunology; Biology; Leukemia; Medicine; In vitro; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002111126,0.0003520729,0.0008225109,0.0008974019,0.0004040031,0.0001360617,0.0004968894,0.0003182452,0.001886904],"category_scores_gemma":[0.0006439068,0.000322661,0.0001019206,0.001865191,0.001672552,0.0001676205,0.0004932503,0.001988902,0.00008731317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002890949,"about_ca_system_score_gemma":0.001358454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007382396,"about_ca_topic_score_gemma":0.00006776034,"domain_scores_codex":[0.9948837,0.001135921,0.0006118023,0.001023407,0.0008969602,0.001448172],"domain_scores_gemma":[0.997591,0.0008357727,0.0001032228,0.0005645888,0.0005855698,0.0003198696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004107013,0.0003126783,0.127023,0.0005251216,0.00008228426,0.0007363533,0.002049607,0.000001373594,0.8641133,0.0000441895,0.0003108348,0.0006942814],"study_design_scores_gemma":[0.006462258,0.002871842,0.04306762,0.0003506706,0.00002359453,0.00006152177,0.002535766,0.0001779789,0.9366136,0.00005936584,0.007399215,0.000376521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723631,0.01929407,0.000005751669,0.004903499,0.0001051958,0.001832133,0.00005634126,0.0001185304,0.001321415],"genre_scores_gemma":[0.9880382,0.00559878,0.0001005943,0.0001631103,0.0002650724,0.0002446272,0.00007690056,0.0001016064,0.005411079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08395533,"threshold_uncertainty_score":0.9999226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1018972086642663,"score_gpt":0.402953893935271,"score_spread":0.3010566852710047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}