{"id":"W3105894177","doi":"10.1101/780460","title":"TNF receptor associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Waterloo; National Research Council Canada; Vancouver Coastal Health Research Institute; Vancouver Coastal Health; University of Toronto; Montreal Neurological Institute and Hospital; Université de Montréal; University of British Columbia; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; University of California, San Diego; Rare Disease Foundation; ALS Society of Canada; McGill University; Muscular Dystrophy Association","keywords":"SOD1; Ubiquitin ligase; Ubiquitin; Superoxide dismutase; Amyotrophic lateral sclerosis; Cell biology; Chemistry; Protein aggregation; Mutation; Neurodegeneration; Biology; Biochemistry; Genetics; Gene; Oxidative stress; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747198,0.0003203609,0.0001654465,0.0002257764,0.0001572585,0.0002671067,0.000133169,0.0002946786,0.001148105],"category_scores_gemma":[0.0001388078,0.0001202216,0.0002739459,0.0001199787,0.00009264507,0.0001198596,0.0002131607,0.000312626,0.0006982284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001953095,"about_ca_system_score_gemma":0.0000523683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001757025,"about_ca_topic_score_gemma":0.0002376063,"domain_scores_codex":[0.9997889,0.00004831482,0.00001658517,0.00003549316,0.000054174,0.0000564627],"domain_scores_gemma":[0.9998512,0.00001877129,0.00004201931,0.00001465952,0.00002438682,0.00004876818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007991643,0.00001526882,0.0004633193,0.00001648754,0.000004755843,0.00007427241,0.000007914687,0.0000132755,0.9990558,0.00001857177,0.00002570227,0.0002246135],"study_design_scores_gemma":[0.00003257886,0.0003086966,0.03351561,0.00001492172,0.00002722689,0.001574543,0.00005729897,0.002049662,0.9592315,0.00007945855,0.003101481,0.000006972998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968935,0.001281601,0.001042507,0.00005419679,0.00002316327,0.000007992563,0.0001349211,0.00003106441,0.000530981],"genre_scores_gemma":[0.996926,0.0003770381,0.0008337543,0.00004254734,0.00001129404,0.000008421109,0.0003896718,0.000008428324,0.001402962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148105,"threshold_uncertainty_score":0.003840804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02249237044954574,"score_gpt":0.250509081678237,"score_spread":0.2280167112286913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}