{"id":"W3106022514","doi":"10.1101/2020.11.12.379115","title":"Neuraminidase inhibitors rewire neutrophil function <i>in vivo</i> in murine sepsis and <i>ex vivo</i> in COVID-19","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; Campus France; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina; Fonds Wetenschappelijk Onderzoek; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ministère de l'Europe et des Affaires Étrangères; Universidade Federal de Santa Catarina; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Neuraminidase; Sialic acid; Neuraminidase inhibitor; Sepsis; Zanamivir; Oseltamivir; Pneumonia; Sialidase; Granulocyte","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002792357,0.000534076,0.0004511154,0.0002130173,0.0001467454,0.0003672644,0.0002119737,0.0003060986,0.001191022],"category_scores_gemma":[0.0001607482,0.0001779125,0.000416877,0.0001584042,0.0002417004,0.0002242863,0.000181074,0.001382507,0.0004169402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603455,"about_ca_system_score_gemma":0.0002146348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005448639,"about_ca_topic_score_gemma":0.0008690076,"domain_scores_codex":[0.9996732,0.00005144355,0.00004801683,0.00006696655,0.00007448427,0.00008580603],"domain_scores_gemma":[0.9998548,0.00001755331,0.00004710905,0.00002085314,0.00001590726,0.0000437914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008206828,0.0001235249,0.0002888064,0.00008112844,0.00002079231,0.00003256735,0.00001591811,0.0001107799,0.9965087,0.00005385633,0.0001744175,0.001768825],"study_design_scores_gemma":[0.0000577897,0.001934962,0.006342758,0.00001754413,0.0000338966,0.0001806387,0.00005333793,0.001658098,0.9878215,0.00005358909,0.001836682,0.000009148203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904286,0.002124802,0.002800717,0.0002169925,0.00015322,0.00008309565,0.002708866,0.0001497614,0.001334016],"genre_scores_gemma":[0.9916825,0.001077554,0.002547072,0.0001901931,0.00001981128,0.00008552033,0.00264645,0.00004074827,0.00171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191022,"threshold_uncertainty_score":0.003984332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01651870898177012,"score_gpt":0.2248364304853503,"score_spread":0.2083177215035802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}