{"id":"W3106098975","doi":"10.1126/scitranslmed.aaz5327","title":"Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis","year":2020,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 European Research Council; Dutch Arthritis Association; Innovative Medicines Initiative; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"Inflammation; Rheumatoid arthritis; Immunology; Medicine; Arthritis; Immunological memory; Immune system; Immunity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001807521,0.0002642064,0.0001661398,0.0004132818,0.0001262837,0.0002302743,0.00008812147,0.0002608628,0.0009881689],"category_scores_gemma":[0.0001538615,0.0001048085,0.0001150935,0.000139565,0.0002644498,0.000192514,0.0002082908,0.0004283742,0.0002800903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000643485,"about_ca_system_score_gemma":0.00008171974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001395344,"about_ca_topic_score_gemma":0.0001309944,"domain_scores_codex":[0.9999146,0.00002162452,0.000006899777,0.00001492463,0.00002270689,0.00001919771],"domain_scores_gemma":[0.9999367,0.00001404319,0.00001522395,0.000007804312,0.000008412206,0.00001772839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004046089,0.00009311509,0.004546749,0.0002450948,0.00001341279,0.0005950889,0.0001927911,0.00006755821,0.977399,0.0003475681,0.0001483724,0.01594663],"study_design_scores_gemma":[0.0004978963,0.006883375,0.3372829,0.0002073107,0.0003520854,0.01519483,0.0008298344,0.002314668,0.5996183,0.003675095,0.03309596,0.00004770248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799442,0.0170446,0.001108154,0.0001042384,0.00004299634,0.00002069495,0.00004709443,0.00008674167,0.001601372],"genre_scores_gemma":[0.9958715,0.002729477,0.0005043335,0.00005340559,0.0000775084,0.00001247609,0.00003515237,0.000004312225,0.0007118054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009881689,"threshold_uncertainty_score":0.003305733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697118795004484,"score_gpt":0.2367220828022475,"score_spread":0.2197508948522026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}