{"id":"W3106260963","doi":"10.1093/ndt/gfaa204","title":"Global Phase 3 programme of vadadustat for treatment of anaemia of chronic kidney disease: rationale, study design and baseline characteristics of dialysis-dependent patients in the INNO2VATE trials","year":2020,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Erythropoietin and Anemia Treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Daiichi Sankyo Europe; Relypsa; National Institutes of Health; Akebia Therapeutics; Angion; ReCor Medical; Gilead Sciences; FibroGen; Satellite Healthcare; Fresenius Medical Care North America; Eli Lilly and Company; AstraZeneca; Celgene; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen","keywords":"Medicine; Kidney disease; Darbepoetin alfa; Clinical endpoint; Dialysis; Internal medicine; Adverse effect; Population; Clinical trial; Demographics; Anemia; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01615378,0.001764929,0.002374458,0.0004904378,0.0006865662,0.001720183,0.001264547,0.001911312,0.007010345],"category_scores_gemma":[0.01052435,0.0008218779,0.002370625,0.001076119,0.001125654,0.001068115,0.0009519418,0.003062104,0.001445179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008976668,"about_ca_system_score_gemma":0.003079858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005002593,"about_ca_topic_score_gemma":0.001755185,"domain_scores_codex":[0.9919608,0.006606241,0.0003226501,0.0003860338,0.0003894008,0.0003347433],"domain_scores_gemma":[0.9965534,0.001062235,0.0007784451,0.0003935026,0.0004832257,0.0007290699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.8639813,0.006406083,0.008192957,0.008745603,0.005106566,0.0002027795,0.0003308002,0.001814544,0.004413828,0.00381272,0.01934673,0.07764608],"study_design_scores_gemma":[0.9294335,0.02981611,0.007827012,0.000858553,0.002253702,0.0002532306,0.00006021476,0.0008025002,0.0008457588,0.001916697,0.02588561,0.00004718294],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.4583687,0.07865607,0.02289545,0.01246944,0.002781522,0.3624572,0.02824555,0.0007480793,0.0333779],"genre_scores_gemma":[0.4899148,0.01194243,0.03724445,0.007762588,0.001076413,0.4353213,0.01078943,0.0002257794,0.005722851],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01615378,"threshold_uncertainty_score":0.08543038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04592804678171736,"score_gpt":0.3239839422316036,"score_spread":0.2780558954498863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}