{"id":"W3106260963","doi":"10.1093/ndt/gfaa204","title":"Global Phase 3 programme of vadadustat for treatment of anaemia of chronic kidney disease: rationale, study design and baseline characteristics of dialysis-dependent patients in the INNO2VATE trials","year":2020,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Erythropoietin and Anemia Treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Daiichi Sankyo Europe; Relypsa; National Institutes of Health; Akebia Therapeutics; Angion; ReCor Medical; Gilead Sciences; FibroGen; Satellite Healthcare; Fresenius Medical Care North America; Eli Lilly and Company; AstraZeneca; Celgene; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen","keywords":"Medicine; Kidney disease; Darbepoetin alfa; Clinical endpoint; Dialysis; Internal medicine; Adverse effect; Population; Clinical trial; Demographics; Anemia; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007086953,0.0001776312,0.001040764,0.000107887,0.00002485754,0.000003427345,0.00006368356,0.00007351321,0.0000205094],"category_scores_gemma":[0.000309767,0.0001201988,0.0001857377,0.0003376548,0.0001239551,0.00004111466,0.000004335815,0.00002889473,1.494353e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006700925,"about_ca_system_score_gemma":0.0002572485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001076071,"about_ca_topic_score_gemma":0.00006880356,"domain_scores_codex":[0.9974726,0.0006656927,0.001171524,0.0002552072,0.0002899161,0.0001450642],"domain_scores_gemma":[0.9981758,0.0006663455,0.0006534242,0.0001630262,0.000238554,0.0001028743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05493543,0.03059365,0.8062193,0.002486758,0.003368679,0.00006197882,0.01437922,0.0005755155,0.02058672,0.0001315343,0.00009049785,0.0665707],"study_design_scores_gemma":[0.1564605,0.04903089,0.7310293,0.00023334,0.03043225,0.000005449863,0.001198482,0.00878587,0.02217396,0.0001001206,0.0002058508,0.0003440096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842312,0.0001932923,0.009673573,0.000967267,0.00002458241,0.003412072,0.001489529,0.000006353285,0.000002134138],"genre_scores_gemma":[0.9947551,0.00119585,0.0009195018,0.0001183648,0.00005323339,0.0002713361,0.002676032,0.000008535018,0.000002037341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1015251,"threshold_uncertainty_score":0.4901566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04592804678171736,"score_gpt":0.3239839422316036,"score_spread":0.2780558954498863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}