{"id":"W3106263790","doi":"10.1038/s42003-020-01397-z","title":"HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Waterloo; York University","funders":"Canadian Institutes of Health Research","keywords":"SH3 domain; Signal transducing adaptor protein; SH2 domain; Immunoglobulin domain; WW domain; Sequence motif; Binding domain; Binding site; Chemistry; Signal transduction; Plasma protein binding; Cell biology; Biology; Receptor; Biochemistry; Receptor tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000774021,0.0002661958,0.0001191516,0.0001292774,0.0002518513,0.0001995797,0.0001569274,0.0003004513,0.002032884],"category_scores_gemma":[0.00007159037,0.00008619129,0.0002024058,0.0001040089,0.000249644,0.0001242732,0.0002603537,0.0004560007,0.0009469985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002882201,"about_ca_system_score_gemma":0.0002105275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003165102,"about_ca_topic_score_gemma":0.0004839893,"domain_scores_codex":[0.9999228,0.00001240082,0.000002611853,0.00001716097,0.0000257472,0.00001928709],"domain_scores_gemma":[0.9999571,0.000005537207,0.00001018037,0.000003223676,0.00000368069,0.00002027173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007346932,0.00001179674,0.0005011532,0.00002002675,0.000004508708,0.0001271653,0.000009532708,0.00007206327,0.997101,0.0003111283,0.0001057026,0.001662383],"study_design_scores_gemma":[0.00002206321,0.0002479922,0.01345397,0.000008762722,0.00001507457,0.001471387,0.00007190528,0.002311034,0.9720514,0.0003073832,0.01003076,0.000008319387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907407,0.001112707,0.004993174,0.0001669552,0.00003044955,0.00001679311,0.0002062741,0.00009574969,0.002637144],"genre_scores_gemma":[0.9943576,0.0003584303,0.002219122,0.00007121461,0.00001132843,0.00001190896,0.0004173599,0.000007682183,0.002545167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002032884,"threshold_uncertainty_score":0.006800652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0473514760692374,"score_gpt":0.2616151488912773,"score_spread":0.21426367282204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}