{"id":"W3106281216","doi":"10.3389/fimmu.2020.605288","title":"Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax™ Provides Protection in a Pre-Clinical Schistosomiasis Model","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McGill University Health Centre; McGill University","funders":"McGill University Health Centre; Public Health Agency; Public Health Agency of Canada; McGill University","keywords":"Schistosoma mansoni; Schistosomiasis; Praziquantel; Immunogenicity; Immunology; Schistosoma; Cathepsin B; Immune system; Biology; Vaccination; Hepatosplenomegaly; Medicine; Pathology; Helminths; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000250329,0.0004375388,0.0009895012,0.0006410132,0.0001778836,0.00001640703,0.0005418191,0.0006698015,0.0001900554],"category_scores_gemma":[0.0006337808,0.0003629818,0.0001588645,0.0006842052,0.001102004,0.0002959336,0.0001874135,0.001870525,0.000140729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391437,"about_ca_system_score_gemma":0.0004389034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112331,"about_ca_topic_score_gemma":0.001984721,"domain_scores_codex":[0.996563,0.0006878798,0.0009874426,0.0008930066,0.00006869437,0.0008000344],"domain_scores_gemma":[0.9988418,0.000167922,0.0003423781,0.0004705603,0.0001127615,0.00006463647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1370006,0.004455429,0.3732057,0.0003676949,0.003753525,0.0006144218,0.04129281,0.003543117,0.3085729,0.001207585,0.01914957,0.1068366],"study_design_scores_gemma":[0.07500828,0.02164358,0.5184554,0.002449211,0.0007690924,0.002135585,0.01222312,0.08006987,0.04860429,0.003852888,0.2290227,0.005765953],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965071,0.004878198,0.02202466,0.004505973,0.00127183,0.00167657,0.0000819287,0.0002557711,0.0002341357],"genre_scores_gemma":[0.9871942,0.0007714753,0.008144487,0.0005254748,0.00004369414,0.0004832997,0.0001320337,0.00006951438,0.002635856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2599687,"threshold_uncertainty_score":0.9998822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03382958094776384,"score_gpt":0.2862493691094152,"score_spread":0.2524197881616513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}