{"id":"W3106281216","doi":"10.3389/fimmu.2020.605288","title":"Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax™ Provides Protection in a Pre-Clinical Schistosomiasis Model","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McGill University Health Centre; McGill University","funders":"McGill University Health Centre; Public Health Agency; Public Health Agency of Canada; McGill University","keywords":"Schistosoma mansoni; Schistosomiasis; Praziquantel; Immunogenicity; Immunology; Schistosoma; Cathepsin B; Immune system; Biology; Vaccination; Hepatosplenomegaly; Medicine; Pathology; Helminths; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001712386,0.0003625762,0.0002536488,0.0001591559,0.00008577092,0.0001452301,0.0001685751,0.00028297,0.001298471],"category_scores_gemma":[0.0001114097,0.0001136656,0.0002102424,0.00009991984,0.0001552748,0.0001877718,0.0001305671,0.0008012188,0.0002253654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001335589,"about_ca_system_score_gemma":0.0002118971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005820301,"about_ca_topic_score_gemma":0.0008729679,"domain_scores_codex":[0.9998775,0.00002399348,0.00001041557,0.00001991998,0.00003106919,0.00003709551],"domain_scores_gemma":[0.9999119,0.00001169953,0.00002551216,0.000007495748,0.00001263783,0.00003073951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001141028,0.0004597866,0.0001844401,0.0001232203,0.00001099962,0.00003643469,0.00002246634,0.0001522102,0.9954715,0.00006435353,0.0001282502,0.002205363],"study_design_scores_gemma":[0.0001270865,0.01494883,0.003327767,0.00001972962,0.00005089571,0.0001284806,0.00003710717,0.001137502,0.9778471,0.00005554764,0.002311885,0.000007989442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969791,0.0009810267,0.000755768,0.0001124839,0.00006796135,0.00003951747,0.0002018987,0.00004411954,0.0008180409],"genre_scores_gemma":[0.9951402,0.001006165,0.0009673679,0.00005805497,0.00001714528,0.0000513616,0.0003275147,0.000006853277,0.002425225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298471,"threshold_uncertainty_score":0.004343748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03382958094776384,"score_gpt":0.2862493691094152,"score_spread":0.2524197881616513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}