{"id":"W3106342198","doi":"10.1016/j.arcmed.2020.10.021","title":"Drug Repurposing: Considerations to Surpass While Re-directing Old Compounds for New Treatments","year":2020,"lang":"en","type":"review","venue":"Archives of Medical Research","topic":"Pharmaceutical Economics and Policy","field":"Economics, Econometrics and Finance","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Repurposing; Drug repositioning; Pharmaceutical industry; Drug; Revenue; Business; Government (linguistics); Risk analysis (engineering); Pharmacology; Medicine; Engineering; Finance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002497689,0.0003168423,0.00211729,0.0007467591,0.0002640936,0.0001537632,0.0008984155,0.000226549,0.0008721261],"category_scores_gemma":[0.007177624,0.0003224012,0.0006236732,0.0004355058,0.0002618061,0.00007106189,0.000571365,0.00100722,0.0004221254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001650975,"about_ca_system_score_gemma":0.00115467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009289976,"about_ca_topic_score_gemma":0.0001319601,"domain_scores_codex":[0.9962387,0.0002196272,0.001632241,0.0008758843,0.0002528695,0.000780671],"domain_scores_gemma":[0.988785,0.008852182,0.0003788652,0.0005428701,0.00004015792,0.001400885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002634856,0.0001514221,0.00002400638,0.002618828,0.0004344646,0.00001493936,0.0008608993,0.000001502319,4.05944e-7,0.1399532,0.08697842,0.7689356],"study_design_scores_gemma":[0.0005449129,0.0001262067,0.000003492893,0.001878249,0.0000403073,0.000007097939,0.00002158956,0.0007664724,0.000005745395,0.04041625,0.95594,0.0002496728],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001357587,0.9364291,0.0003868102,0.01733898,0.0003575117,0.001762822,0.000888501,0.00003196359,0.04279075],"genre_scores_gemma":[0.0002411006,0.9928944,0.00200906,0.0007203184,0.0007790711,0.0002763213,0.0001183205,0.0000819301,0.002879528],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8689616,"threshold_uncertainty_score":0.9999228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4380893411526562,"score_gpt":0.4898583205616452,"score_spread":0.051768979408989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}