{"id":"W3106443431","doi":"10.1016/s1474-4422(20)30368-9","title":"Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study","year":2020,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Agence Nationale de la Recherche; Alnylam Pharmaceuticals","keywords":"Medicine; Transthyretin; Polyneuropathy; Clinical trial; Amyloidosis; Internal medicine; Placebo; Pediatrics; Physical therapy; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004259735,0.002035546,0.003567747,0.0005463114,0.0005471608,0.001615328,0.0009587972,0.002245923,0.002347511],"category_scores_gemma":[0.002959176,0.0005816344,0.003192116,0.0005473877,0.001840466,0.002538867,0.0004530697,0.004067522,0.000927662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008925042,"about_ca_system_score_gemma":0.0008909345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007095723,"about_ca_topic_score_gemma":0.0007395427,"domain_scores_codex":[0.9985935,0.000635913,0.0001116304,0.0002463522,0.0001804847,0.0002321006],"domain_scores_gemma":[0.9966921,0.0009058316,0.0008262696,0.0004766396,0.0002926472,0.0008065325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9305528,0.01894695,0.006496547,0.0003271594,0.002165472,0.0001943317,0.0001739523,0.0009283894,0.005632787,0.00008073247,0.0007918962,0.03370892],"study_design_scores_gemma":[0.4960905,0.4298097,0.06427137,0.0000883212,0.002957597,0.0003241654,0.0001768556,0.001759197,0.002599109,0.0004865014,0.001281483,0.0001552078],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967912,0.00144777,0.0002362938,0.0001613834,0.00008212761,0.0001855661,0.000571574,0.00003807633,0.0004860372],"genre_scores_gemma":[0.9955122,0.0009070574,0.0003667742,0.0003138553,0.0002368056,0.0003922455,0.00106883,0.00001884672,0.001183459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004259735,"threshold_uncertainty_score":0.02252787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0371038334949078,"score_gpt":0.2932776886921494,"score_spread":0.2561738551972416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}