{"id":"W3106668659","doi":"10.1101/2020.11.30.405712","title":"Balancing positive and negative selection: <i>in vivo</i> evolution of <i>Candida lusitaniae MRR1</i>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Julius-Maximilians-Universität Würzburg; Dartmouth College; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Cystic Fibrosis Foundation; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Population; Allele; Virulence; Genetics; Drug resistance; Fluconazole; Microbiology; Gene; Antifungal","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005499232,0.0002707676,0.0002933997,0.0003021251,0.0003071413,0.0006127093,0.0004717267,0.0004499429,0.0008334217],"category_scores_gemma":[0.0007962711,0.0001512715,0.0002196085,0.0001821256,0.0004219386,0.0002678552,0.0006086096,0.0007643768,0.000237638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004474756,"about_ca_system_score_gemma":0.0002422562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011345,"about_ca_topic_score_gemma":0.001393805,"domain_scores_codex":[0.9996433,0.0001071404,0.00002118123,0.00008235695,0.00005949574,0.00008650902],"domain_scores_gemma":[0.9994462,0.0001452557,0.0001317586,0.00009508537,0.0000751987,0.0001064531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00010563,0.00003901231,0.006225506,0.00001480732,0.00001289315,0.00008661041,0.00006199455,0.0003228769,0.9901584,0.0002613014,0.00005736288,0.002653585],"study_design_scores_gemma":[0.00006488052,0.001671311,0.3345474,0.00003479491,0.0000871947,0.003433262,0.00104752,0.02566258,0.6259281,0.001027084,0.006385589,0.0001102554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978416,0.00007402941,0.001232261,0.0000669873,0.000005264032,0.00001037933,0.00007950563,0.0000227013,0.0006672353],"genre_scores_gemma":[0.9984252,0.00004076022,0.0008937422,0.00005923088,0.000005135652,0.00001257875,0.0001654229,0.00002065013,0.0003772821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011345,"threshold_uncertainty_score":0.003246725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008057999460139877,"score_gpt":0.221503560934106,"score_spread":0.2134455614739661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}