{"id":"W3106686816","doi":"10.1371/journal.pgen.1009216","title":"A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Eye Institute; National Institutes of Health; University of Chicago","keywords":"Biology; Cell fate determination; Cell biology; Effector; Drosophila melanogaster; Ommatidium; MAPK cascade; Signal transduction; Receptor tyrosine kinase; MAPK/ERK pathway; Robustness (evolution); Gene isoform; Genetics; Compound eye; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770291,0.000134413,0.0001277263,0.00002302794,0.00006601886,0.00004680668,0.0001442083,0.00008760354,0.00001540777],"category_scores_gemma":[0.00003508572,0.0001136814,0.00004180745,0.0001416738,0.00003916716,0.000002871972,0.00004182167,0.00008725049,0.000008655776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001093576,"about_ca_system_score_gemma":0.00002930511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002630157,"about_ca_topic_score_gemma":0.00002797887,"domain_scores_codex":[0.9990349,0.0001202762,0.0001981764,0.0002846813,0.0001645137,0.0001973934],"domain_scores_gemma":[0.9996793,0.00002510323,0.0000414969,0.0001151854,0.00007119541,0.00006771199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001060191,0.0001678208,0.03645282,0.00009763688,0.00006423896,0.000006464105,0.0005895238,0.006129075,0.9511275,0.0001850174,0.003118982,0.001000706],"study_design_scores_gemma":[0.005730364,0.002034869,0.2300574,0.0001423613,0.0001964878,0.00001528847,0.001751464,0.01576165,0.713961,0.0003751906,0.02891284,0.001061012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848718,0.002269296,0.00970225,0.002346095,0.00005583292,0.0005125858,0.00002022494,0.000008440759,0.0002134855],"genre_scores_gemma":[0.9972576,0.0002144432,0.0004012037,0.001712091,0.0001702445,0.00003999555,0.0001744509,0.00001216629,0.00001778178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2371665,"threshold_uncertainty_score":0.4635791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428506193597629,"score_gpt":0.213347690620678,"score_spread":0.1990626286847017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}