{"id":"W3106721187","doi":"10.1038/s41416-020-01194-9","title":"Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity","year":2020,"lang":"en","type":"letter","venue":"British Journal of Cancer","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Phosphatase; Gain of function; Mutant; Identification (biology); Phosphorylation; Function (biology); Enzyme; Biochemistry; Biology; Cancer; Computational biology; Cancer research; Chemistry; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002085672,0.0005700676,0.0008719603,0.0003351852,0.0006438721,0.001207174,0.001006808,0.01207036,0.002984504],"category_scores_gemma":[0.005656531,0.0003216815,0.0006063218,0.0002463357,0.002547129,0.00478297,0.0009314846,0.01233448,0.002543801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002044755,"about_ca_system_score_gemma":0.0009864589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009435195,"about_ca_topic_score_gemma":0.001323012,"domain_scores_codex":[0.9993017,0.0002001919,0.00008779633,0.0001153877,0.000209175,0.000085712],"domain_scores_gemma":[0.9982029,0.001091921,0.000166172,0.0001061342,0.0002091127,0.0002238638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006833305,0.0001846035,0.001914214,0.00079971,0.00007148868,0.01169523,0.0002249578,0.0004824957,0.007107461,0.04918596,0.792705,0.1349455],"study_design_scores_gemma":[0.0002045563,0.0001801057,0.0009014076,0.0001880266,0.00004105752,0.01208734,0.0003521975,0.001019424,0.001760318,0.07490965,0.9083039,0.0000519778],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001649515,0.03138877,0.0006649027,0.9488559,0.01465908,0.00001010465,0.00004913724,0.0000495905,0.002673076],"genre_scores_gemma":[0.03179342,0.05045539,0.001595205,0.7975685,0.1041625,0.00005761535,0.00006174131,0.00003002175,0.01427552],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01207036,"threshold_uncertainty_score":0.01483577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03365848946839758,"score_gpt":0.2838661680722473,"score_spread":0.2502076786038497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}