{"id":"W3106767035","doi":"10.1186/s13063-020-04925-8","title":"Safety and Efficacy of Ixekizumab and Antiviral Treatment for Patients with COVID-19: A structured summary of a study protocol for a Pilot Randomized Controlled Trial","year":2020,"lang":"en","type":"letter","venue":"Trials","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"National Natural Science Foundation of China; Hunan Provincial Innovation Foundation for Postgraduate; Central South University; National Science Foundation","keywords":"Ixekizumab; Medicine; ARDS; Randomized controlled trial; Clinical trial; Immune dysregulation; Internal medicine; Immunology; Immune system; Secukinumab; Arthritis; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02851889,0.006080337,0.00963503,0.002039538,0.003488937,0.003605223,0.0027742,0.007299488,0.04496042],"category_scores_gemma":[0.02502644,0.002791528,0.006079475,0.002542818,0.003417404,0.003676486,0.001804696,0.007187719,0.009167846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003540552,"about_ca_system_score_gemma":0.01456755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009759687,"about_ca_topic_score_gemma":0.002353104,"domain_scores_codex":[0.9834621,0.0099361,0.002347477,0.001398507,0.001392846,0.001462917],"domain_scores_gemma":[0.9881821,0.002958352,0.00262233,0.001513083,0.002859713,0.001864346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.856396,0.01822835,0.001655309,0.03275291,0.00265644,0.0004618165,0.0004733318,0.002407351,0.004334845,0.007025012,0.02588269,0.04772597],"study_design_scores_gemma":[0.89171,0.03752572,0.003590227,0.006797179,0.001570038,0.0001625437,0.0001533902,0.002689823,0.001182713,0.003623491,0.05082035,0.0001744402],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.00181233,0.000591555,0.001565796,0.0002899053,0.0003875781,0.9935414,0.0009196179,0.00008373528,0.0008080596],"genre_scores_gemma":[0.001938001,0.0003109099,0.002091442,0.0002579142,0.00008631533,0.9947634,0.0002209089,0.000006189164,0.0003248615],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04496042,"threshold_uncertainty_score":0.1508242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1489104014543439,"score_gpt":0.4906283782849847,"score_spread":0.3417179768306409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}