{"id":"W3106771074","doi":"10.1016/j.ijpharm.2020.120121","title":"Development of a formulation platform for a spray-dried, inhalable tuberculosis vaccine candidate","year":2020,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Alberta","keywords":"Trehalose; Excipient; Squalene; Adjuvant; Dry-powder inhaler; Spray drying; Emulsion; Tuberculosis vaccines; Chemistry; Liposome; Chromatography; Mycobacterium tuberculosis; Tuberculosis; Medicine; Immunology; Biochemistry; Inhaler","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616069,0.00009862816,0.0002338241,0.0001795299,0.00003693161,0.00001505301,0.0001358942,0.0000532261,0.0001647606],"category_scores_gemma":[0.000115578,0.00008293168,0.0001378712,0.0001078817,0.00001064973,0.0002011768,0.00003382818,0.0001602216,0.000007602177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298386,"about_ca_system_score_gemma":0.0003327984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.283195e-7,"about_ca_topic_score_gemma":0.000001664266,"domain_scores_codex":[0.9985464,0.000009303808,0.000755468,0.00008280324,0.0004954786,0.0001105225],"domain_scores_gemma":[0.9981008,0.00005181538,0.0004789431,0.00004450835,0.001163618,0.0001603368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009465125,0.0006752035,0.0128627,0.0005333775,0.002890066,0.0001463727,0.008046297,0.001912295,0.8800359,0.0009117431,0.003936692,0.07858424],"study_design_scores_gemma":[0.007022352,0.0001780613,0.0005864127,0.0001445646,0.0002001096,0.0001313939,0.0002528167,0.01336408,0.8227543,0.0000246611,0.1552306,0.0001106997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849055,0.0001947427,0.01024028,0.003371883,0.0005683971,0.000261601,0.00002817756,0.00001146053,0.0004179137],"genre_scores_gemma":[0.9840627,0.00006844673,0.01312347,0.002157595,0.0004909697,0.000002978759,0.00002797438,0.00001463345,0.00005123797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1512939,"threshold_uncertainty_score":0.3381856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0681149265706822,"score_gpt":0.3673036500775614,"score_spread":0.2991887235068793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}