{"id":"W3106821130","doi":"10.1158/1538-7445.epimetab20-po-051","title":"Abstract PO-051: Metabolic alterations reveal epigenetic vulnerabilities in breast cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Epigenetics; Breast cancer; Cancer; Cancer research; Biology; DNA methylation; Epigenetic therapy; Chromatin; Cancer epigenetics; Cancer cell; Chromatin remodeling; Histone; Medicine; Bioinformatics; Genetics; Histone methyltransferase; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001545115,0.0003463216,0.0002301339,0.0008458984,0.0002534517,0.0005959856,0.0002097001,0.0003989888,0.02036164],"category_scores_gemma":[0.0001654076,0.0001680062,0.000182726,0.0006957547,0.000207163,0.0002418391,0.0003314334,0.0005371391,0.00354088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006465489,"about_ca_system_score_gemma":0.000265584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291439,"about_ca_topic_score_gemma":0.00160975,"domain_scores_codex":[0.9999183,0.00001331327,0.000004439952,0.00001678283,0.00003079206,0.00001641505],"domain_scores_gemma":[0.9999073,0.00001586852,0.00002146144,0.000008398052,0.00002200425,0.0000249105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002817092,0.0002532213,0.008145871,0.0004821091,0.0000620077,0.0009550473,0.00007349929,0.0005659178,0.8702759,0.002807558,0.02957628,0.08398557],"study_design_scores_gemma":[0.0001745008,0.001244283,0.1761662,0.0001217735,0.0001304989,0.004977435,0.0002091378,0.001365288,0.6465745,0.003235801,0.165753,0.00004751087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7778394,0.03436699,0.007473897,0.01203115,0.001520617,0.0002929217,0.03696297,0.001236101,0.128276],"genre_scores_gemma":[0.8635349,0.01294601,0.004019312,0.001079128,0.0002982488,0.0001043128,0.01721616,0.0001251753,0.1006768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02036164,"threshold_uncertainty_score":0.06811643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05186866660508613,"score_gpt":0.3715510532302269,"score_spread":0.3196823866251407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}