{"id":"W3106840429","doi":"10.1002/jhet.4195","title":"Concise synthesis of chiral pyrazolo[4,3‐<i>f</i>] [1,4]oxazepines and pyrazolo[4,3‐<i>f</i>] [1,4]thiazepines bearing pyrazole unit","year":2020,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada; Bristol-Myers Squibb","keywords":"Chemistry; Pyrazole; Imine; Stereochemistry; Intramolecular force; Aryl; Combinatorial chemistry; Alkyl; Organic chemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174214,0.0005698728,0.000446028,0.0002334036,0.000220825,0.0002142376,0.0003859657,0.0003008039,0.001981405],"category_scores_gemma":[0.0001701954,0.0001823418,0.0001772621,0.0002817255,0.0001710945,0.0003291875,0.0003154959,0.0003270413,0.0006857641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517397,"about_ca_system_score_gemma":0.000639786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004689533,"about_ca_topic_score_gemma":0.001585569,"domain_scores_codex":[0.9998735,0.00001834812,0.00001418869,0.00001856805,0.00002811587,0.00004718943],"domain_scores_gemma":[0.9999303,0.000006934631,0.00001880566,0.000006030574,0.00001588155,0.00002205934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002373617,0.000232426,0.0002683402,0.001030959,0.0000373554,0.001373951,0.0003246061,0.003488206,0.9325231,0.007240018,0.002458738,0.05078489],"study_design_scores_gemma":[0.0001991703,0.00268887,0.001250752,0.00005605883,0.00005613416,0.001133754,0.00009980994,0.003703059,0.9374472,0.001224962,0.05206101,0.00007912501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8532407,0.01261149,0.08556586,0.0006075554,0.0004836016,0.001137844,0.002641001,0.001096489,0.0426154],"genre_scores_gemma":[0.9490573,0.007161465,0.03180616,0.0001228021,0.00006759862,0.0003232076,0.001080421,0.00005378936,0.01032717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001981405,"threshold_uncertainty_score":0.006628454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02759817567545461,"score_gpt":0.235422758511556,"score_spread":0.2078245828361014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}