{"id":"W3106887103","doi":"10.1016/j.leukres.2020.106489","title":"Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study⋆","year":2020,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Princess Margaret Cancer Centre","funders":"F. Hoffmann-La Roche","keywords":"Cytarabine; Medicine; Myeloid leukemia; Adverse effect; Internal medicine; Gastroenterology; Refractory (planetary science); Myeloid; Leukemia; Acute leukemia; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006555836,0.0008477067,0.0009040905,0.0004245281,0.00032999,0.0005675444,0.0006727512,0.0006611679,0.002190287],"category_scores_gemma":[0.000212649,0.0002844065,0.0005829689,0.0003223388,0.0006123722,0.00049895,0.0001898061,0.002129608,0.0004480422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005252312,"about_ca_system_score_gemma":0.0007357012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008673386,"about_ca_topic_score_gemma":0.001944904,"domain_scores_codex":[0.9997876,0.00007571864,0.00001007369,0.00003402864,0.00002914927,0.00006333677],"domain_scores_gemma":[0.9997873,0.00003804569,0.00004484636,0.00002867056,0.00001112924,0.00009017726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.09982152,0.02302997,0.002081236,0.0003684731,0.0004045157,0.0001552167,0.0002007736,0.001631967,0.8244582,0.0009513371,0.004443471,0.04245321],"study_design_scores_gemma":[0.08242214,0.3809912,0.0267441,0.00005988711,0.0009122646,0.0009059478,0.0002621833,0.002976852,0.4839592,0.0005567173,0.02013808,0.00007142077],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948158,0.001866606,0.0006450356,0.0002735747,0.0001009734,0.0002602928,0.0007948463,0.00007688234,0.00116596],"genre_scores_gemma":[0.9906474,0.002306757,0.001480607,0.000195175,0.00008625577,0.0003584253,0.002381523,0.00004802693,0.002495864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002190287,"threshold_uncertainty_score":0.007327259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1025090926772272,"score_gpt":0.3992120490464178,"score_spread":0.2967029563691906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}