{"id":"W3106888500","doi":"10.1016/j.ejpb.2020.11.016","title":"DNA-crosslinked alginate and layered microspheres to modulate the release of encapsulated FITC-dextran","year":2020,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dextran; Lysozyme; Self-healing hydrogels; Calcium alginate; Covalent bond; Chemistry; DNA; Drug delivery; Drug carrier; Microparticle; Biophysics; PEG ratio; Polymer chemistry; Calcium; Chemical engineering; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001847957,0.0003071094,0.0001711981,0.0001038328,0.00006898829,0.0002995826,0.0001779636,0.0003251111,0.0007727841],"category_scores_gemma":[0.000199033,0.0001475067,0.0002061155,0.0001258741,0.0001660833,0.000255703,0.0001524206,0.0004710325,0.0001822739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00042763,"about_ca_system_score_gemma":0.0003032711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001062566,"about_ca_topic_score_gemma":0.001597661,"domain_scores_codex":[0.9998693,0.00001314264,0.00001384641,0.00003654798,0.00002493494,0.00004220602],"domain_scores_gemma":[0.999843,0.00003238074,0.00004840562,0.00001074384,0.00001894705,0.0000465515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005515281,0.00001131562,0.0000240196,0.00001746408,0.000003710064,0.00001016688,0.000008748048,0.00005998148,0.9992107,0.00006075645,0.00000911968,0.0005287759],"study_design_scores_gemma":[0.00001088776,0.0001262421,0.0003398412,0.000001498169,0.00001202553,0.00001910364,0.000003430347,0.0005395199,0.9983558,0.00001101563,0.0005763823,0.00000434425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917988,0.001128511,0.0057411,0.00008955797,0.00008241266,0.00003057707,0.0001204909,0.0001080348,0.0009006033],"genre_scores_gemma":[0.9924677,0.0004052941,0.004084059,0.00004952388,0.00001367922,0.00001737119,0.00009770919,0.0000289916,0.002835644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062566,"threshold_uncertainty_score":0.00310272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1190186356469546,"score_gpt":0.3933868222301733,"score_spread":0.2743681865832188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}