{"id":"W3106888500","doi":"10.1016/j.ejpb.2020.11.016","title":"DNA-crosslinked alginate and layered microspheres to modulate the release of encapsulated FITC-dextran","year":2020,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dextran; Lysozyme; Self-healing hydrogels; Calcium alginate; Covalent bond; Chemistry; DNA; Drug delivery; Drug carrier; Microparticle; Biophysics; PEG ratio; Polymer chemistry; Calcium; Chemical engineering; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002081044,0.0005232395,0.0007107269,0.0001437989,0.000357542,0.00007074281,0.000742322,0.0001399063,0.0001443585],"category_scores_gemma":[0.0001875954,0.0003974843,0.0002461906,0.0005667599,0.0006194313,0.0002263576,0.0003854165,0.001545958,0.00004129445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004883921,"about_ca_system_score_gemma":0.0001014246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003929777,"about_ca_topic_score_gemma":6.06638e-7,"domain_scores_codex":[0.9955381,0.001489488,0.001488945,0.0004483,0.0003990174,0.0006361976],"domain_scores_gemma":[0.9965897,0.0003956886,0.0009984504,0.0002470295,0.0005239077,0.001245276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002019679,0.0001711849,0.002976346,0.0002332569,0.0007030705,0.0004389091,0.003985611,0.007911869,0.9331729,0.00006874731,0.001271794,0.04704658],"study_design_scores_gemma":[0.01120276,0.001472136,0.003471586,0.000165673,0.00117104,0.000699546,0.0009305608,0.05779756,0.4891461,0.00006216759,0.4329557,0.0009252529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983501,0.008431589,0.001308701,0.004546094,0.0008960977,0.0006694116,0.0001632587,0.00005426326,0.0004295892],"genre_scores_gemma":[0.9880702,0.004894734,0.0008324498,0.005452111,0.0005359087,0.000002375362,0.000004741074,0.00009284919,0.0001145923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4440269,"threshold_uncertainty_score":0.9998477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1190186356469546,"score_gpt":0.3933868222301733,"score_spread":0.2743681865832188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}