{"id":"W3106906902","doi":"10.1158/1535-7163.mct-20-0130","title":"Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells <i>In Vitro</i> and <i>In Vivo</i>","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hong Kong Polytechnic University; University Grants Committee","keywords":"Chemistry; Cancer research; Breast cancer; Peptide; Cancer cell; Cytotoxicity; In vitro; Biochemistry; Cancer; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702452,0.0002127083,0.0004039657,0.0001324804,0.00002643722,0.00002108203,0.00006320547,0.0001125037,0.00002390726],"category_scores_gemma":[0.000006604854,0.000214084,0.00004324022,0.0004494231,0.00003860014,0.0001028138,0.00003615115,0.0002602053,5.276021e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002719185,"about_ca_system_score_gemma":0.00008676958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004949806,"about_ca_topic_score_gemma":0.002680738,"domain_scores_codex":[0.9985747,0.00008563973,0.0004304821,0.000431763,0.0002320838,0.0002452943],"domain_scores_gemma":[0.9994748,0.00003102472,0.0001425777,0.0001650261,0.00005794406,0.0001286496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005446768,0.0001387353,0.001316939,0.00009433686,0.00003725281,0.00001825245,0.001348586,0.0003344122,0.9774488,0.00002179076,0.0000464855,0.01374768],"study_design_scores_gemma":[0.004707185,0.0002563999,0.007690179,0.0002777303,0.00005568636,0.000007062108,0.0002510833,0.00206349,0.9829897,0.00006619724,0.001408036,0.000227261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894246,0.001138555,0.001012385,0.007106422,0.0001032606,0.0006562992,0.0005040975,0.00001678186,0.00003756523],"genre_scores_gemma":[0.9911155,0.002708069,0.000342316,0.005614147,0.00004948981,0.00009115746,0.00002422432,0.00003380819,0.00002131176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01352042,"threshold_uncertainty_score":0.8730093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828867646139766,"score_gpt":0.2798321028020886,"score_spread":0.2615434263406909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}