{"id":"W3106906902","doi":"10.1158/1535-7163.mct-20-0130","title":"Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells <i>In Vitro</i> and <i>In Vivo</i>","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hong Kong Polytechnic University; University Grants Committee","keywords":"Chemistry; Cancer research; Breast cancer; Peptide; Cancer cell; Cytotoxicity; In vitro; Biochemistry; Cancer; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004888,0.0003523755,0.0002218306,0.00009127762,0.0001142243,0.0001389679,0.0001760513,0.0002212894,0.0009351132],"category_scores_gemma":[0.00007938165,0.0001138173,0.0002391062,0.0001165975,0.0001472467,0.0001052452,0.0001088262,0.0003728562,0.0003197933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003225552,"about_ca_system_score_gemma":0.0001653758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00068931,"about_ca_topic_score_gemma":0.0006694781,"domain_scores_codex":[0.9998869,0.00001961277,0.0000109094,0.00002398923,0.00002894304,0.00002963918],"domain_scores_gemma":[0.9999398,0.00001441679,0.00001648344,0.000006517957,0.000007371415,0.00001537964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007734911,0.00001918456,0.00005111236,0.0000129976,0.000003238025,0.00002199744,0.000002961523,0.00004739358,0.9995193,0.00001729022,0.00003109015,0.0001960977],"study_design_scores_gemma":[0.00000599748,0.0002018098,0.0006444075,0.000001166914,0.00000448288,0.00009388485,0.000004769699,0.0004943986,0.9980162,0.000005461138,0.0005257498,0.000001564591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956098,0.0007926254,0.001994443,0.00006772563,0.00003425804,0.00002082074,0.000378871,0.00005914479,0.001042185],"genre_scores_gemma":[0.9921314,0.0004687718,0.002966569,0.00006444676,0.000007005554,0.00003859737,0.001589943,0.00001817205,0.002715186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009351132,"threshold_uncertainty_score":0.003128231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828867646139766,"score_gpt":0.2798321028020886,"score_spread":0.2615434263406909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}