{"id":"W3106944690","doi":"10.1101/2020.11.25.397679","title":"Selective BCL-X <sub>L</sub> Antagonists Eliminate Infected Cells from a Primary Cell Model of HIV Latency but not from <i>Ex Vivo</i> Reservoirs","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic","funders":"","keywords":"Ex vivo; Viremia; Biology; Immunology; In vivo; Apoptosis; Virology; Cancer research; Human immunodeficiency virus (HIV); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108992,0.0003853699,0.0004464624,0.0001570938,0.0001597815,0.0004054105,0.0002930108,0.0002222224,0.002174155],"category_scores_gemma":[0.00008239299,0.000149531,0.0002203156,0.00009999056,0.000188323,0.0001977306,0.0001428705,0.00108501,0.0005749678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002435585,"about_ca_system_score_gemma":0.0002122271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005657107,"about_ca_topic_score_gemma":0.001138235,"domain_scores_codex":[0.9998394,0.00002251024,0.00001413463,0.00002159287,0.00003382863,0.00006844834],"domain_scores_gemma":[0.9998691,0.0000357913,0.00002188417,0.00001570109,0.00001191632,0.00004554484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00013149,0.00008364088,0.00008574187,0.00002451212,0.000004244479,0.00002328943,0.00001184112,0.0000407236,0.9986952,0.00005310295,0.00007089146,0.0007753224],"study_design_scores_gemma":[0.00003026007,0.0008128877,0.001063821,0.000003912389,0.00001208077,0.0001273551,0.00001907314,0.0006014733,0.9963201,0.00001381587,0.0009931684,0.000001971198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947698,0.001208793,0.001698395,0.000106331,0.00004697072,0.00005120303,0.0003184981,0.0001235979,0.001676464],"genre_scores_gemma":[0.9936581,0.0006288796,0.001612893,0.00006613566,0.00001939673,0.00005695257,0.0004945426,0.00002932433,0.003433744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002174155,"threshold_uncertainty_score":0.007273316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326304874226212,"score_gpt":0.2035298872710269,"score_spread":0.1902668385287648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}