{"id":"W3106991527","doi":"10.1021/acschemneuro.0c00380","title":"Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Mental Health; Western College of Veterinary Medicine, University of Saskatchewan; Government of Canada; National Institutes of Health; Canada Foundation for Innovation; Saskatchewan Health Research Foundation; Massachusetts General Hospital","keywords":"Kinome; GSK-3; Biology; Biochemistry; Drug discovery; Peptide; Binding site; Glycogen synthase; Small molecule; Kinase; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254127,0.0003151823,0.000250392,0.0001210936,0.0001141791,0.0002519238,0.0001967977,0.0003068282,0.000576328],"category_scores_gemma":[0.0001852825,0.0001040048,0.0002176457,0.00007115796,0.0001705988,0.0001869784,0.0001418868,0.0004680491,0.0002372552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020913,"about_ca_system_score_gemma":0.0001957169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000130877,"about_ca_topic_score_gemma":0.0001412984,"domain_scores_codex":[0.9999279,0.00000967899,0.000007719532,0.00001592561,0.0000256493,0.00001315645],"domain_scores_gemma":[0.9999082,0.00001648657,0.00003168319,0.000005597602,0.000009743118,0.00002819934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006475981,0.00003217363,0.00008955351,0.00003529429,0.000003778857,0.00008813922,0.000009088508,0.0001608264,0.9975471,0.0001333171,0.00003616795,0.001799726],"study_design_scores_gemma":[0.0000479043,0.0009415611,0.002161804,0.000007106784,0.00002344916,0.001113007,0.00001316008,0.001234171,0.9897523,0.00006513003,0.004631433,0.000008978172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831111,0.002929332,0.01076694,0.0001773741,0.00006087857,0.0001262118,0.0005121469,0.00004988896,0.002266207],"genre_scores_gemma":[0.9813814,0.002258428,0.0124187,0.0001657643,0.00004460353,0.00008454349,0.001641504,0.00001779188,0.001987355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000576328,"threshold_uncertainty_score":0.001927972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087020248801545,"score_gpt":0.2177642598269497,"score_spread":0.2068940573389343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}