{"id":"W3106991527","doi":"10.1021/acschemneuro.0c00380","title":"Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Mental Health; Western College of Veterinary Medicine, University of Saskatchewan; Government of Canada; National Institutes of Health; Canada Foundation for Innovation; Saskatchewan Health Research Foundation; Massachusetts General Hospital","keywords":"Kinome; GSK-3; Biology; Biochemistry; Drug discovery; Peptide; Binding site; Glycogen synthase; Small molecule; Kinase; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006057231,0.0000764108,0.00009144854,0.00001328123,0.00003065286,0.00001461762,0.0001243175,0.00005058063,0.000002170355],"category_scores_gemma":[0.0004731804,0.00006003812,0.00002173649,0.0001717618,0.0001601218,0.00001212627,0.00009033494,0.0000496268,4.429684e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003921731,"about_ca_system_score_gemma":0.00002564901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000958485,"about_ca_topic_score_gemma":0.00000174237,"domain_scores_codex":[0.9992676,0.00004113375,0.0002248834,0.000270315,0.0001188506,0.00007724267],"domain_scores_gemma":[0.9996164,0.00001472431,0.0001364485,0.0001456683,0.00003947317,0.00004728528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002193884,0.00003417568,0.0003542049,0.00001608821,0.000001360816,6.706911e-7,0.00006626017,0.000002299821,0.9989746,0.00002223468,0.000003167366,0.0003055189],"study_design_scores_gemma":[0.0003380539,0.00005538717,0.01820227,0.00002207352,0.000006394024,0.00000104056,0.00001607538,0.001000241,0.980224,0.00003250521,0.00004215098,0.00005985708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972538,0.00002303282,0.001961777,0.0004302275,0.00004532135,0.0002242559,0.00005433406,0.000005204483,0.000002089113],"genre_scores_gemma":[0.9995837,0.00001326316,0.00006301682,0.0001873584,0.00003776965,0.0000156043,0.00008525491,0.000005890572,0.000008094192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01875068,"threshold_uncertainty_score":0.2448283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087020248801545,"score_gpt":0.2177642598269497,"score_spread":0.2068940573389343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}