{"id":"W3107001125","doi":"10.1016/j.trecan.2020.10.013","title":"Why Tumor Genetic Heterogeneity May Require Rethinking Cancer Genesis and Treatment","year":2020,"lang":"en","type":"review","venue":"Trends in cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Jewish General Hospital; McGill University","funders":"","keywords":"Biology; Cancer; Cancer cell; Genetic heterogeneity; Selection (genetic algorithm); Gene; Cancer research; Somatic evolution in cancer; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001519343,0.0006309842,0.001293192,0.001093604,0.0002159241,0.001513794,0.0008793598,0.001467205,0.002997148],"category_scores_gemma":[0.00201062,0.0002157249,0.0004240854,0.001007525,0.0009562297,0.00190907,0.000719785,0.003752685,0.001759953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001160249,"about_ca_system_score_gemma":0.001545753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298286,"about_ca_topic_score_gemma":0.003228948,"domain_scores_codex":[0.9996979,0.00008397403,0.00002665737,0.00005751192,0.00009600869,0.00003791201],"domain_scores_gemma":[0.9990025,0.0005706082,0.00005579078,0.00003716616,0.0002559417,0.00007800766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009781338,0.0000379818,0.000302771,0.005230562,0.00008124534,0.0001914786,0.00004904842,0.0004954353,0.0014901,0.01887757,0.07739919,0.8957468],"study_design_scores_gemma":[0.00002124121,0.0000469942,0.000481465,0.001872601,0.0000753877,0.0006243453,0.00005855711,0.000137879,0.0003272529,0.01055239,0.9857837,0.00001830761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000104817,0.9936643,0.0004764482,0.003693887,0.0009825142,0.000003709836,0.00002829275,0.00001655035,0.001029608],"genre_scores_gemma":[0.001217552,0.9932843,0.000564661,0.002610772,0.001278601,0.000009558257,0.00004960454,0.000006435477,0.0009784206],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002997148,"threshold_uncertainty_score":0.01002651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07287996616264049,"score_gpt":0.3712801955048742,"score_spread":0.2984002293422338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}