{"id":"W3107143805","doi":"10.3390/molecules25225477","title":"Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Mitacs","keywords":"Autosomal dominant polycystic kidney disease; Polycystic kidney disease; Melatonin; Cyst; Medicine; Kidney; Renal function; Internal medicine; Caspase; Cancer research; Endocrinology; Pathology; Biology; Apoptosis; Programmed cell death; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046301,0.0002759073,0.0002119609,0.0003714837,0.0002595395,0.0002311218,0.0002898064,0.0004794704,0.0009782354],"category_scores_gemma":[0.00007020096,0.0001275023,0.0002805018,0.0001445245,0.0002882116,0.0002039873,0.0002171594,0.0006165187,0.0001627853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004648407,"about_ca_system_score_gemma":0.0002730411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00265545,"about_ca_topic_score_gemma":0.003933025,"domain_scores_codex":[0.999885,0.00001820184,0.0000158069,0.00002909786,0.00003515607,0.00001671142],"domain_scores_gemma":[0.9999088,0.00001405696,0.00002671981,0.000009901266,0.00001066591,0.00002997178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001206927,0.00003574993,0.0001822279,0.00005029831,0.000005076573,0.0001055879,0.00001982171,0.0001157593,0.9983601,0.0002272288,0.0000669286,0.0007105449],"study_design_scores_gemma":[0.00005669802,0.0006664636,0.005234444,0.00001698734,0.00003430827,0.0004576762,0.00008383788,0.002282708,0.9860184,0.0001463935,0.004984829,0.00001733736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916152,0.001222426,0.003008011,0.0002894448,0.00006955928,0.0001022047,0.001449559,0.0001219356,0.002121787],"genre_scores_gemma":[0.9854558,0.001176482,0.006458614,0.0001473393,0.000008646636,0.0001467637,0.0008618662,0.00004037119,0.005704011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00265545,"threshold_uncertainty_score":0.005279958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166175858335839,"score_gpt":0.2210507415208174,"score_spread":0.2093889829374591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}