{"id":"W3107143983","doi":"10.18632/aging.202225","title":"In search of preventative strategies: novel high-CBD &lt;i&gt;cannabis sativa&lt;/i&gt; extracts modulate ACE2 expression in COVID-19 gateway tissues","year":2020,"lang":"en","type":"article","venue":"Aging","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Lethbridge","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Cannabidiol; Biology; Angiotensin-converting enzyme 2; TMPRSS2; Cannabis sativa; Inflammation; Pharmacology; Medicine; Immunology; Cannabis; Disease; Internal medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008088572,0.0003025754,0.0006587601,0.0004504025,0.00008321867,0.00006824651,0.000293183,0.0001622511,0.0006182399],"category_scores_gemma":[0.0005092326,0.0002750845,0.0001076768,0.001069555,0.0002336702,0.0005585864,0.0002526171,0.0006123512,0.00002034853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003890296,"about_ca_system_score_gemma":0.00116284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001020463,"about_ca_topic_score_gemma":0.0004077034,"domain_scores_codex":[0.9967512,0.0002530121,0.0006634529,0.0006849692,0.0009254517,0.000721928],"domain_scores_gemma":[0.9986108,0.00007656788,0.0001530642,0.0003800482,0.0001808614,0.0005986391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004957669,0.0003562736,0.001304796,0.001030976,0.00003772445,0.000478342,0.02616425,0.00319893,0.953155,0.000692466,0.01085782,0.002227601],"study_design_scores_gemma":[0.02093798,0.002054397,0.1470802,0.003931704,0.00008928715,0.0001011838,0.02330758,0.01087528,0.6953102,0.001650053,0.09322176,0.001440351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549907,0.00138555,0.001188141,0.04003748,0.00007770212,0.001114593,0.0000395307,0.00005613626,0.001110137],"genre_scores_gemma":[0.9949337,0.0002887455,0.0007987542,0.0008044744,0.0001520157,0.0001040329,0.00004123333,0.00005769199,0.002819356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2578448,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03792820452413539,"score_gpt":0.3515607581103838,"score_spread":0.3136325535862484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}