{"id":"W3107143983","doi":"10.18632/aging.202225","title":"In search of preventative strategies: novel high-CBD &lt;i&gt;cannabis sativa&lt;/i&gt; extracts modulate ACE2 expression in COVID-19 gateway tissues","year":2020,"lang":"en","type":"article","venue":"Aging","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Lethbridge","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Cannabidiol; Biology; Angiotensin-converting enzyme 2; TMPRSS2; Cannabis sativa; Inflammation; Pharmacology; Medicine; Immunology; Cannabis; Disease; Internal medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124146,0.0003976548,0.0005355965,0.000592778,0.0003312414,0.0004597317,0.0003007026,0.0003825176,0.003663428],"category_scores_gemma":[0.0001276156,0.0001435826,0.0005543185,0.0002674231,0.0002786397,0.0004090852,0.0002358982,0.001250271,0.0006250357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004672354,"about_ca_system_score_gemma":0.000416738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002044674,"about_ca_topic_score_gemma":0.005741472,"domain_scores_codex":[0.9999391,0.000006875,0.00000412355,0.00001481033,0.00001844103,0.00001658574],"domain_scores_gemma":[0.9999473,0.000007033665,0.00001163058,0.000005181405,0.00001254188,0.00001623408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001383251,0.0003950567,0.0006151168,0.001036032,0.0000853298,0.0002855693,0.00005307416,0.0002117146,0.9581116,0.0006854536,0.001426862,0.03571093],"study_design_scores_gemma":[0.0004915059,0.004936466,0.0198319,0.0003754949,0.0005819396,0.001327177,0.000321299,0.001702008,0.8640784,0.001315712,0.1049269,0.0001111031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9143222,0.05184647,0.009230966,0.00297934,0.0006255513,0.0004027649,0.003800085,0.0006501625,0.01614248],"genre_scores_gemma":[0.9426891,0.02550188,0.01280158,0.002092647,0.0001210252,0.0002030629,0.00307888,0.0001402619,0.01337158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003663428,"threshold_uncertainty_score":0.01225537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03792820452413539,"score_gpt":0.3515607581103838,"score_spread":0.3136325535862484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}