{"id":"W3107176433","doi":"10.1021/acsinfecdis.0c00599","title":"Development of Antibiotics That Dysregulate the <i>Neisserial</i> ClpP Protease","year":2020,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Proteases; Biology; Protease; Microbiology; Neisseria; Bacteria; Proteome; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002368272,0.0001121133,0.00009945132,0.000007514926,0.00008924666,0.00001903984,0.0001239011,0.00006636846,0.0000143241],"category_scores_gemma":[0.00007398359,0.00007687241,0.00005327307,0.00007794403,0.00007358556,0.000003859659,0.00009410726,0.00004329488,0.000006476842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005068687,"about_ca_system_score_gemma":0.0000608661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001537026,"about_ca_topic_score_gemma":0.000001378374,"domain_scores_codex":[0.9994335,0.00002518007,0.0001511741,0.0001815068,0.00009295419,0.0001156824],"domain_scores_gemma":[0.9996189,0.000005222596,0.00009281793,0.0001462913,0.00005078931,0.00008597462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006576652,0.00003319486,0.01590663,0.00005580692,0.0000473787,5.384969e-7,0.00006481778,0.000006515696,0.9813859,0.00003709136,0.0002821941,0.002114149],"study_design_scores_gemma":[0.0002285553,0.00006565005,0.02020281,0.000008467894,0.00003127192,0.00000196409,0.00001869895,0.00001049583,0.9701115,0.00004808259,0.009153226,0.0001192991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988407,0.0002209668,0.0002635167,0.0002546128,0.00009331953,0.0002043989,0.00003337018,0.00002304236,0.00006599594],"genre_scores_gemma":[0.9987075,0.00004496724,0.00009584264,0.0006263233,0.0002273538,0.00000253504,0.0002675521,0.00001155943,0.00001635172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01127445,"threshold_uncertainty_score":0.3134766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196482005666192,"score_gpt":0.2197397832844213,"score_spread":0.2077749632277594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}