{"id":"W3107286542","doi":"10.1186/s12860-020-00330-w","title":"Biochemical and genetic analysis of Ecm14, a conserved fungal pseudopeptidase","year":2020,"lang":"en","type":"article","venue":"BMC Molecular and Cell Biology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dalhousie University; Andrews University; Johns Hopkins University","keywords":"Saccharomyces cerevisiae; Biology; Gene; Yeast; Conserved sequence; Biochemistry; Carboxypeptidase; Genetics; Enzyme; Function (biology); Endopeptidase; Auxotrophy; Hypothetical protein; Peptide sequence; Mutant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003843752,0.0001051134,0.0003889927,0.0001208983,0.00001881859,0.000005166065,0.00003114908,0.00009926414,0.0001532323],"category_scores_gemma":[0.00004701635,0.00008845826,0.0001716743,0.0003466825,0.0001701941,0.000006265889,0.0000351208,0.00007166019,0.000003905275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003319356,"about_ca_system_score_gemma":0.00002971682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002256328,"about_ca_topic_score_gemma":0.000004319753,"domain_scores_codex":[0.9992641,0.00007049812,0.0002127642,0.0002762205,0.00005384771,0.0001226115],"domain_scores_gemma":[0.9995419,0.00003264236,0.00005780803,0.0001223625,0.00004250274,0.000202753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008738328,0.0000440161,0.04402816,0.00007781335,0.000292978,0.00004971823,0.00004813402,0.000005515835,0.9550704,0.00006090859,0.00008121978,0.0001537388],"study_design_scores_gemma":[0.002248511,0.0005103247,0.02576644,0.00003398958,0.003407573,0.0000368934,0.0001658021,0.01134907,0.9559457,0.00003576521,0.000270542,0.0002293952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950002,0.001024628,0.002920102,0.0004129882,0.000002358194,0.00007472876,0.00002936858,0.00001433365,0.0005213098],"genre_scores_gemma":[0.9964483,0.00005785279,0.001727912,0.001628152,0.0000156149,0.000002611301,0.00009015554,0.000005953455,0.00002346405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01826172,"threshold_uncertainty_score":0.3607223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541399393650681,"score_gpt":0.2476981737121311,"score_spread":0.2322841797756243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}