{"id":"W3107325631","doi":"10.21203/rs.3.rs-33898/v1","title":"Oxidative stress-induced parkin misfolding, aggregation, and toxicity","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Parkin; Oxidative stress; Toxicity; Protein aggregation; Chemistry; Biochemistry; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002678406,0.0002982421,0.0002158617,0.0003548785,0.0001702244,0.0003437373,0.00008447438,0.0002510163,0.002038829],"category_scores_gemma":[0.0001547712,0.00008950727,0.0001898081,0.0002723719,0.0002034371,0.0001792502,0.0002295087,0.000330497,0.0005656533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002857971,"about_ca_system_score_gemma":0.0001769208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002085685,"about_ca_topic_score_gemma":0.0002346331,"domain_scores_codex":[0.9998761,0.00001521877,0.00001131146,0.00002297086,0.00005251428,0.00002180886],"domain_scores_gemma":[0.9998831,0.00001748158,0.00003351345,0.00001568847,0.0000248892,0.0000253456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005584798,0.0001339829,0.004741703,0.0002804536,0.00004181211,0.0008015922,0.00007234627,0.0003237212,0.9785428,0.0007625874,0.0008470119,0.01289344],"study_design_scores_gemma":[0.00005177303,0.0004638342,0.04136977,0.00002798077,0.00004458685,0.002901861,0.00008406526,0.001572202,0.9420334,0.002279446,0.009161926,0.000009187461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819826,0.006171903,0.004862935,0.0005130491,0.0001427546,0.00005266263,0.0007442805,0.000147912,0.005381851],"genre_scores_gemma":[0.9891276,0.002555411,0.002279773,0.0001073755,0.00004828181,0.0000224984,0.0008215943,0.00002039425,0.005017154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002038829,"threshold_uncertainty_score":0.00682056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1489578468280886,"score_gpt":0.4335854527977491,"score_spread":0.2846276059696605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}