{"id":"W3107350394","doi":"10.1002/alz.12229","title":"Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Institute on Aging; European Regional Development Fund; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; National Institutes of Health; Fundació la Marató de TV3; Generalitat de Catalunya; Consortium canadien en neurodégénérescence associée au vieillissement; McGill University","keywords":"Nerve growth factor; Cerebrospinal fluid; Internal medicine; Alzheimer's disease; Endocrinology; Neurotrophin; Neurology; Medicine; Pathology; Psychology; Disease; Receptor; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004353516,0.0004840211,0.0005039167,0.001520576,0.0005136932,0.000746989,0.0001998425,0.0006546633,0.001221436],"category_scores_gemma":[0.001332603,0.0002428072,0.0002676708,0.0006549878,0.0003288397,0.0004817436,0.0003690844,0.0005290858,0.0002709006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003559476,"about_ca_system_score_gemma":0.0002914634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002210501,"about_ca_topic_score_gemma":0.001750978,"domain_scores_codex":[0.9997371,0.00004556533,0.0000306994,0.00008516029,0.00005932018,0.00004204025],"domain_scores_gemma":[0.999332,0.000165427,0.0001611426,0.00003186204,0.0001193109,0.0001901498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002821314,0.0001958805,0.9766832,0.00004534324,0.00009595357,0.001606285,0.0002380981,0.00004378139,0.012967,0.00003046324,0.00008311513,0.005189532],"study_design_scores_gemma":[0.00003270031,0.001219945,0.9924935,0.00001811344,0.00009292613,0.003314847,0.0002534338,0.0001320352,0.002006281,0.00005512006,0.0003700326,0.00001101075],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988506,0.0005440211,0.00008241014,0.00001250897,0.000008865783,0.00001000335,0.0001752282,0.000003411951,0.0003129299],"genre_scores_gemma":[0.9989587,0.0002629547,0.0002103513,0.00002927506,0.00001672563,0.00001371446,0.0002616751,0.000002308896,0.0002442159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002210501,"threshold_uncertainty_score":0.004395247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08424135587807928,"score_gpt":0.3479556870662192,"score_spread":0.2637143311881399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}