{"id":"W3107373086","doi":"10.3389/fmicb.2020.575334","title":"Conjugation of Synthetic Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields Active and Stable Antimicrobials","year":2020,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Universidad de Granada","keywords":"Nisin; Lipid II; Lantibiotics; Antimicrobial; Chemistry; Lanthionine; Biochemistry; Lactococcus lactis; Peptide; Combinatorial chemistry; Biology; Bacteria; Enzyme; Organic chemistry; Biosynthesis; Lactic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659839,0.0003537912,0.0001625171,0.0001241094,0.0001015338,0.0002167727,0.0001636775,0.0003365172,0.0007213424],"category_scores_gemma":[0.0002356132,0.0001297556,0.0001718274,0.0001276076,0.0002070302,0.000302266,0.0002208149,0.0004416354,0.0002888151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002560094,"about_ca_system_score_gemma":0.00008938828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001382215,"about_ca_topic_score_gemma":0.0002405557,"domain_scores_codex":[0.9998612,0.00002819995,0.00001291404,0.00003129074,0.0000355786,0.00003088175],"domain_scores_gemma":[0.999856,0.00002775769,0.00006245147,0.000012201,0.00001656972,0.00002499451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002854192,0.000006596699,0.00003911624,0.00001854287,0.000001969947,0.00002513316,0.000007247468,0.00007423737,0.9989893,0.0000735535,0.000008889307,0.00072677],"study_design_scores_gemma":[0.000003888156,0.0001407452,0.0003844447,0.000002033972,0.000002940835,0.00007587645,0.000006467508,0.0003648584,0.9980224,0.00002049177,0.0009729266,0.000002932464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854326,0.0007038918,0.0120339,0.00006860767,0.00002360369,0.00003775868,0.00009668056,0.00008021065,0.001522754],"genre_scores_gemma":[0.9885706,0.0003817497,0.009161556,0.00004666836,0.00000687491,0.00003049616,0.0001858331,0.00001988538,0.001596303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007213424,"threshold_uncertainty_score":0.002413094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031745797751803,"score_gpt":0.2145172803892918,"score_spread":0.2041998224117738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}