{"id":"W3107394471","doi":"10.1016/j.ajpath.2020.11.006","title":"Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease","year":2020,"lang":"en","type":"review","venue":"American Journal Of Pathology","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Children's Discovery Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Musculoskeletal Research Center, Washington University in St. Louis; U.S. Department of Defense; Mallinckrodt Pharmaceuticals; Doris Duke Charitable Foundation; Office of the Assistant Secretary for Health; Institute of Clinical and Translational Sciences","keywords":"Ryanodine receptor; Homeostasis; Endoplasmic reticulum; Calcium metabolism; Endocrinology; Internal medicine; Unfolded protein response; Biology; Inositol trisphosphate receptor; Inositol; Cell biology; Calcium; Receptor; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00123666,0.00121312,0.002197021,0.002718514,0.0003569785,0.001717791,0.001189681,0.001791614,0.004700531],"category_scores_gemma":[0.001289474,0.0003561767,0.0004962613,0.002940188,0.0006780855,0.002000914,0.001416391,0.002246988,0.003763609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008002593,"about_ca_system_score_gemma":0.001886391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00103052,"about_ca_topic_score_gemma":0.002015799,"domain_scores_codex":[0.9997533,0.0000393727,0.00005100476,0.00004119343,0.00008707645,0.00002799464],"domain_scores_gemma":[0.9994116,0.0002169943,0.00009294143,0.00001642633,0.0001909131,0.00007117585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002094061,0.00007645916,0.0001858505,0.02287702,0.0001202071,0.0002217495,0.00005242723,0.0002170521,0.001197566,0.003276677,0.06933375,0.9022318],"study_design_scores_gemma":[0.00005330995,0.00009213865,0.000662455,0.005532974,0.0002638464,0.0006171658,0.00005823922,0.00006378898,0.0002208243,0.002040795,0.9903738,0.00002068328],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003208437,0.9986123,0.00005691277,0.000329489,0.0004747593,0.000002392781,0.00001137847,0.000006146895,0.0004746013],"genre_scores_gemma":[0.0002327927,0.9986658,0.00008150264,0.0002159526,0.0004733354,0.000002717853,0.00001624852,8.087363e-7,0.0003107423],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004700531,"threshold_uncertainty_score":0.0157249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04333208074395533,"score_gpt":0.3782059751153729,"score_spread":0.3348738943714176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}