{"id":"W3107475249","doi":"10.1016/j.molcel.2020.10.038","title":"Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Cancer Institute; National Institutes of Health; Queen's University","keywords":"Biology; Gene isoform; Histone; Linker; Dynamics (music); Computational biology; Cell biology; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002137807,0.0001950698,0.0002079947,0.00001944365,0.00005444524,0.00001808809,0.0001563954,0.0001026146,0.00001235411],"category_scores_gemma":[0.000006319715,0.0001537288,0.00006278232,0.00004353696,0.0001199242,0.000001740082,0.0001461441,0.00008070599,6.227929e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001361927,"about_ca_system_score_gemma":0.00002208236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001129042,"about_ca_topic_score_gemma":0.00003823946,"domain_scores_codex":[0.9992057,0.00001748166,0.0001897657,0.0002997759,0.0001157215,0.0001715351],"domain_scores_gemma":[0.999485,0.000002737005,0.0001175489,0.0002470222,0.00003681352,0.0001109385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003960953,0.00004853093,0.00561515,0.0001762335,0.00005935804,0.00001380864,0.0001109585,0.0001023265,0.9926042,0.0008067395,0.00005748719,0.0003656098],"study_design_scores_gemma":[0.002157769,0.001874986,0.02648248,0.00002669491,0.0001366353,0.00002806535,0.0002402417,0.005832039,0.9603123,0.001000623,0.001152887,0.0007552612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993018,0.00050255,0.005296299,0.0001426469,0.00001908704,0.0001404304,0.00004137934,0.00000995321,0.0008296299],"genre_scores_gemma":[0.9984115,0.00003252229,0.0009303319,0.0001520096,0.00002925466,0.000004954086,0.0003171354,0.00003734411,0.00008493813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03229187,"threshold_uncertainty_score":0.6268879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003941980886170353,"score_gpt":0.2007688125764295,"score_spread":0.1968268316902591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}