{"id":"W3107491342","doi":"10.7554/elife.59018","title":"Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Malaria Research and Control","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; National Institutes of Health; Ontario Ministry of Economic Development, Job Creation and Trade; Hospital for Sick Children; Sick Kids Foundation; Office of Science; Canada Foundation for Innovation; Ontario Research Foundation; Canadian Institutes of Health Research; Compute Canada; Canadian Institute for Advanced Research; Brookhaven National Laboratory; Argonne National Laboratory; U.S. Department of Energy","keywords":"Circumsporozoite protein; Plasmodium berghei; Plasmodium falciparum; Monoclonal antibody; Biology; Antibody; Virology; Plasmodium (life cycle); Malaria vaccine; Epitope; Structural motif; Computational biology; Malaria; Genetics; Immunology; Biochemistry; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005463271,0.0002084245,0.0001005075,0.00005944418,0.0002038493,0.0002684362,0.0002297114,0.0001481821,0.0009185047],"category_scores_gemma":[0.00009429899,0.0001555116,0.0001258009,0.00004569958,0.0002111289,0.0001511389,0.0001240968,0.0003655491,0.0001464762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000559235,"about_ca_system_score_gemma":0.0003726709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004205763,"about_ca_topic_score_gemma":0.005339555,"domain_scores_codex":[0.9999684,0.000003519049,0.000001067706,0.000005593792,0.00000864697,0.00001266171],"domain_scores_gemma":[0.999977,0.000003608566,0.00000744088,0.000001384603,0.000002990203,0.00000765887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002916293,0.0001555248,0.00663748,0.00008468462,0.00004877794,0.0003432877,0.00009396143,0.0286124,0.954202,0.002614241,0.0007786423,0.006137337],"study_design_scores_gemma":[0.0002103302,0.0007257037,0.03094277,0.00003493188,0.00007699007,0.000477324,0.0003006732,0.3651524,0.5921562,0.0009488288,0.008929352,0.00004440631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963503,0.0001798287,0.001715566,0.00007465691,0.00000783105,0.000007294498,0.00004102214,0.00003979174,0.001583786],"genre_scores_gemma":[0.9978418,0.0002614085,0.001152531,0.00003908678,0.000001480698,0.00000627481,0.0001106583,0.00001137996,0.000575354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004205763,"threshold_uncertainty_score":0.008362591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454701835330226,"score_gpt":0.2634019224257905,"score_spread":0.2488549040724883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}