{"id":"W3107491342","doi":"10.7554/elife.59018","title":"Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Malaria Research and Control","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; National Institutes of Health; Ontario Ministry of Economic Development, Job Creation and Trade; Hospital for Sick Children; Sick Kids Foundation; Office of Science; Canada Foundation for Innovation; Ontario Research Foundation; Canadian Institutes of Health Research; Compute Canada; Canadian Institute for Advanced Research; Brookhaven National Laboratory; Argonne National Laboratory; U.S. Department of Energy","keywords":"Circumsporozoite protein; Plasmodium berghei; Plasmodium falciparum; Monoclonal antibody; Biology; Antibody; Virology; Plasmodium (life cycle); Malaria vaccine; Epitope; Structural motif; Computational biology; Malaria; Genetics; Immunology; Biochemistry; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309444,0.0001185567,0.0002469151,0.00002490195,0.00006977457,0.00001442627,0.0001724928,0.00006705803,0.000202595],"category_scores_gemma":[0.0003410674,0.00007951823,0.00009845654,0.0001785134,0.00008031881,0.00006097848,0.0001025718,0.0003183831,0.00001664758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002382666,"about_ca_system_score_gemma":0.0001721672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008269532,"about_ca_topic_score_gemma":0.000004194939,"domain_scores_codex":[0.9986228,0.00005685449,0.0002503919,0.0002237595,0.0005802485,0.000265893],"domain_scores_gemma":[0.999268,0.000021034,0.00008823507,0.0002957607,0.0001102236,0.0002167385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004101928,0.00002630822,0.01268821,0.0001763583,0.00007303655,0.00002763496,0.0002885574,0.000005602712,0.9800279,0.0003235934,0.004871518,0.001081045],"study_design_scores_gemma":[0.007001251,0.0009003831,0.1231203,0.0003879842,0.00009549072,0.00003854583,0.0003107023,0.003838704,0.8407279,0.00007895597,0.02312109,0.000378602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854738,0.0004486003,0.00005787633,0.011782,0.00008964896,0.0007287149,0.000022333,0.0000459176,0.001351171],"genre_scores_gemma":[0.9979844,0.000008689136,0.00007954847,0.0009129569,0.000294356,0.00001855975,0.0000176651,0.00001886085,0.0006649669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1393,"threshold_uncertainty_score":0.3242659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454701835330226,"score_gpt":0.2634019224257905,"score_spread":0.2488549040724883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}