{"id":"W3107511586","doi":"10.1093/brain/awaa399","title":"Time course of phosphorylated-tau181 in blood across the Alzheimer’s disease spectrum","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Wallenberg Centre for Molecular and Translational Medicine; Instituto de Salud Carlos III; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; Paulon Säätiö; Orionin Tutkimussäätiö; Servier; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Eisai; Northern California Institute for Research and Education; Ministerio de Ciencia, Innovación y Universidades; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; Biogen; BioClinica; European Commission; AbbVie; Hjärnfonden; F. Hoffmann-La Roche; University of Southern California; H2020 European Research Council; Gun och Bertil Stohnes Stiftelse; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; Novartis Pharmaceuticals Corporation; Alzheimerfonden; Alzheimer's Drug Discovery Foundation; Alzheimer's Association; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Alzheimer's disease; Disease; Broad spectrum; Medicine; Psychology; Neuroscience; Internal medicine; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656895,0.0001652457,0.0002822648,0.0000253374,0.00006098763,0.00001436604,0.0001618635,0.0000452166,0.0004738173],"category_scores_gemma":[0.0001419917,0.0001086424,0.0001482044,0.0003442939,0.0002307663,0.00005518577,0.00008628623,0.0001900164,0.0003256087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001622381,"about_ca_system_score_gemma":0.0003178804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008001509,"about_ca_topic_score_gemma":0.00001300185,"domain_scores_codex":[0.9986351,0.0000810219,0.0002307049,0.0002757175,0.0003552023,0.000422269],"domain_scores_gemma":[0.9988197,0.0001243532,0.00006155953,0.0003479687,0.00003656617,0.0006098177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01365119,0.01241279,0.8156614,0.0003951578,0.04383627,0.0119681,0.009661686,0.0001218513,0.003385487,0.0006424373,0.07290348,0.01536015],"study_design_scores_gemma":[0.014613,0.001390342,0.9547836,0.0002560375,0.002948382,0.00003854614,0.001049536,0.003326194,0.01791206,0.0005439453,0.002668971,0.0004694381],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9484363,0.01873481,0.000001313082,0.03122394,0.00001889907,0.0007404404,0.0002363454,0.000050878,0.0005571194],"genre_scores_gemma":[0.9982487,0.00009741241,0.00001358853,0.001332453,0.00008600545,0.00003100236,0.00008166335,0.00002752165,0.00008167438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1391222,"threshold_uncertainty_score":0.5187967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02722445666758042,"score_gpt":0.3208012865801649,"score_spread":0.2935768299125845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}