{"id":"W3107511586","doi":"10.1093/brain/awaa399","title":"Time course of phosphorylated-tau181 in blood across the Alzheimer’s disease spectrum","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Wallenberg Centre for Molecular and Translational Medicine; Instituto de Salud Carlos III; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; Paulon Säätiö; Orionin Tutkimussäätiö; Servier; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Eisai; Northern California Institute for Research and Education; Ministerio de Ciencia, Innovación y Universidades; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; Biogen; BioClinica; European Commission; AbbVie; Hjärnfonden; F. Hoffmann-La Roche; University of Southern California; H2020 European Research Council; Gun och Bertil Stohnes Stiftelse; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; Novartis Pharmaceuticals Corporation; Alzheimerfonden; Alzheimer's Drug Discovery Foundation; Alzheimer's Association; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Alzheimer's disease; Disease; Broad spectrum; Medicine; Psychology; Neuroscience; Internal medicine; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004945514,0.0002494056,0.0003810019,0.0005825179,0.0003079826,0.0005607955,0.0002280785,0.0004331626,0.0005992848],"category_scores_gemma":[0.001545088,0.0002308078,0.0001912638,0.0006694047,0.0001916309,0.0003961029,0.0002871113,0.0004362005,0.0002104566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109191,"about_ca_system_score_gemma":0.0001311651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002322561,"about_ca_topic_score_gemma":0.002081745,"domain_scores_codex":[0.9997328,0.00004343069,0.00001972977,0.0001276096,0.00003955661,0.00003685472],"domain_scores_gemma":[0.9991764,0.000145809,0.00035373,0.00007081701,0.0001502332,0.0001029398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002079042,0.00008878431,0.9812602,0.00003066911,0.0001286218,0.0003348387,0.0003429438,0.0001706887,0.00824971,0.00006185389,0.0002448661,0.007007786],"study_design_scores_gemma":[0.000007148269,0.0001664566,0.9986279,0.000003049983,0.0000206036,0.0002643521,0.00006326246,0.0001466751,0.0004695247,0.00004668322,0.0001800483,0.000004472727],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987434,0.000323853,0.0001757948,0.00002247908,0.000003389325,0.000004693278,0.0004866989,0.00001148121,0.0002283701],"genre_scores_gemma":[0.9983027,0.0001625795,0.0002519483,0.00002601192,0.000008268561,0.00001464398,0.000929616,0.000004662173,0.0002995417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002322561,"threshold_uncertainty_score":0.004618049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02722445666758042,"score_gpt":0.3208012865801649,"score_spread":0.2935768299125845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}