{"id":"W3107560264","doi":"10.3390/cancers12123619","title":"Advances in Targeting Cancer-Associated Genes by Designed siRNA in Prostate Cancer","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Small interfering RNA; Cancer; Prostate cancer; Nanomedicine; Metastasis; Medicine; RNA interference; Cancer research; Biology; Bioinformatics; Gene; RNA; Nanotechnology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003413593,0.0006928034,0.0007976718,0.001638323,0.0002003714,0.0005264999,0.0004990251,0.0006620198,0.001936908],"category_scores_gemma":[0.0002460958,0.0002366328,0.000400402,0.001370976,0.0002953781,0.0007037611,0.0004466886,0.001073414,0.001467207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003665255,"about_ca_system_score_gemma":0.0006052554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000650801,"about_ca_topic_score_gemma":0.001187502,"domain_scores_codex":[0.9998926,0.00001563835,0.00001344599,0.00002197603,0.00004347224,0.00001278564],"domain_scores_gemma":[0.9999093,0.00004204188,0.00001221826,0.000003228673,0.00002415512,0.000008909381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005105745,0.00007783252,0.0001530505,0.01723263,0.00006431274,0.0002678525,0.00007158011,0.0006321524,0.02001818,0.005624713,0.01164089,0.9441659],"study_design_scores_gemma":[0.00001245258,0.0001776761,0.00069023,0.001260827,0.0001058514,0.001406768,0.00003652489,0.0001961222,0.005587953,0.00158004,0.9889212,0.000024333],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003219195,0.99715,0.0006414041,0.0001260573,0.0001405688,0.000008097981,0.00002122455,0.00001798489,0.001572692],"genre_scores_gemma":[0.001117809,0.9974524,0.0005006564,0.00009351191,0.00005051425,0.000009568033,0.00003227577,0.000002252168,0.0007410489],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001936908,"threshold_uncertainty_score":0.006479621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824682952660057,"score_gpt":0.3178293785626314,"score_spread":0.2995825490360309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}