{"id":"W3107596204","doi":"10.1021/acschemneuro.0c00636","title":"Roflumilast, a cAMP-Specific Phosphodiesterase-4 Inhibitor, Reduces Oxidative Stress and Improves Synapse Functions in Human Cortical Neurons Exposed to the Excitotoxin Quinolinic Acid","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Health and Medical Research Council; Australian Research Council; Macquarie University","keywords":"CREB; Synapsin I; Quinolinic acid; Synaptophysin; Brain-derived neurotrophic factor; Cyclic adenosine monophosphate; Cell biology; Chemistry; Neurotrophic factors; Biology; Biochemistry; Transcription factor; Synaptic vesicle; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000106507,0.0004206779,0.0005702255,0.0003663123,0.0001794765,0.0001554028,0.000323018,0.0004026562,0.0009071913],"category_scores_gemma":[0.000118626,0.0001628527,0.0003998962,0.0001727859,0.0001635405,0.0002329788,0.0001428223,0.0005312625,0.0002189856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588121,"about_ca_system_score_gemma":0.0003008546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001216352,"about_ca_topic_score_gemma":0.001959741,"domain_scores_codex":[0.9999155,0.00001151173,0.00001074461,0.00001787293,0.00001490855,0.00002952231],"domain_scores_gemma":[0.9999564,0.000006589755,0.00001268811,0.000005048562,0.000008018266,0.0000113424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007993401,0.0001895599,0.0001267036,0.0001421213,0.0000177192,0.0001050038,0.00003231788,0.0000505151,0.9932584,0.00002658648,0.0001465483,0.005105208],"study_design_scores_gemma":[0.0001932525,0.003884327,0.005698515,0.00001618733,0.00006945046,0.0006216656,0.00004003833,0.0004785651,0.9866931,0.00004429612,0.00224911,0.00001159209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919791,0.005397399,0.00104129,0.0001593083,0.00005164491,0.00003632575,0.0003242289,0.0001444425,0.0008661874],"genre_scores_gemma":[0.9929886,0.003052895,0.001325062,0.00007247186,0.00001934606,0.00007977402,0.0006247849,0.00001465037,0.001822527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216352,"threshold_uncertainty_score":0.00303483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02249672988742188,"score_gpt":0.2521878071522928,"score_spread":0.229691077264871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}