{"id":"W3107596204","doi":"10.1021/acschemneuro.0c00636","title":"Roflumilast, a cAMP-Specific Phosphodiesterase-4 Inhibitor, Reduces Oxidative Stress and Improves Synapse Functions in Human Cortical Neurons Exposed to the Excitotoxin Quinolinic Acid","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Health and Medical Research Council; Australian Research Council; Macquarie University","keywords":"CREB; Synapsin I; Quinolinic acid; Synaptophysin; Brain-derived neurotrophic factor; Cyclic adenosine monophosphate; Cell biology; Chemistry; Neurotrophic factors; Biology; Biochemistry; Transcription factor; Synaptic vesicle; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009983622,0.000210329,0.0001712818,0.0000365115,0.0002350711,0.00009604006,0.0002914377,0.0001030159,0.000005975612],"category_scores_gemma":[0.0003999458,0.0001643991,0.0000521012,0.0003569284,0.0004357442,0.00002503892,0.0003241059,0.0002725266,0.00000665015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001587176,"about_ca_system_score_gemma":0.00004340211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004090882,"about_ca_topic_score_gemma":0.00001073954,"domain_scores_codex":[0.998294,0.00009606441,0.0003152959,0.0007638033,0.0002047045,0.0003261436],"domain_scores_gemma":[0.9992894,0.00004559787,0.00007299815,0.0002881598,0.00005094958,0.0002528949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001265163,0.00008101184,0.0006531809,0.000006491553,0.00000258356,0.00000509917,0.0002852527,0.00002841925,0.997155,0.00001394553,0.001334478,0.0003080989],"study_design_scores_gemma":[0.0004164375,0.0004164485,0.008007192,0.00001666283,0.000005970588,0.00001038851,0.0002449023,0.0001062693,0.9871297,0.000006074516,0.003449449,0.0001904947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964291,0.0001763562,0.0003449644,0.002317425,0.0002974657,0.0003448949,0.00002622271,0.00002832676,0.0000352384],"genre_scores_gemma":[0.996665,0.00006067616,0.00004089995,0.002817026,0.0002280202,0.00006167762,0.0000319032,0.00001731095,0.00007749099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01002521,"threshold_uncertainty_score":0.6703999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02249672988742188,"score_gpt":0.2521878071522928,"score_spread":0.229691077264871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}