{"id":"W3107639073","doi":"10.1158/2643-3249.lymphoma20-po-62","title":"Abstract PO-62: Overcoming venetoclax resistance in B-cell malignancies by antagonism of stromal TGF-beta-mediated drug resistance","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Stromal cell; Cancer research; Tumor microenvironment; Stroma; Venetoclax; Drug resistance; Biology; Leukemia; Medicine; Immunology; Chemistry; Chronic lymphocytic leukemia; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009171719,0.0002266735,0.0001916243,0.0002103844,0.0001226051,0.0002867575,0.0001619808,0.0001566086,0.002233829],"category_scores_gemma":[0.00006127449,0.00007680873,0.0001439702,0.0001504345,0.0001587901,0.0001353411,0.000123969,0.0008930933,0.0004515314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001289484,"about_ca_system_score_gemma":0.0002474095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005363789,"about_ca_topic_score_gemma":0.0009805537,"domain_scores_codex":[0.9999474,0.000007565996,0.000003486057,0.000008867726,0.00001378733,0.00001881732],"domain_scores_gemma":[0.9999706,0.000004400675,0.000006309299,0.000003794965,0.000002960075,0.00001199257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005368409,0.0003959347,0.0003906036,0.0001056015,0.00001346475,0.00008634292,0.00002379519,0.0002720044,0.9802148,0.0003559237,0.0004965229,0.01710808],"study_design_scores_gemma":[0.0003841325,0.005212266,0.007538442,0.00002800271,0.00005998951,0.0007580583,0.00005856299,0.002731763,0.9655204,0.0001972161,0.01750086,0.00001039888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878013,0.004052036,0.001511058,0.0003135431,0.0001038186,0.00008841209,0.0003312004,0.0001495927,0.005648922],"genre_scores_gemma":[0.9929449,0.001735152,0.00122602,0.00009214864,0.0000261901,0.00004125479,0.0003990375,0.00001355137,0.003521811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002233829,"threshold_uncertainty_score":0.007472932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165107891578242,"score_gpt":0.245988149186268,"score_spread":0.2343370702704856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}