{"id":"W3107682875","doi":"10.1021/acs.jafc.0c05544","title":"A Novel Angiotensin Converting Enzyme 2 (ACE2) Activating Peptide: A Reflection of 10 Years of Research on a Small Peptide Ile-Arg-Trp (IRW)","year":2020,"lang":"en","type":"review","venue":"Journal of Agricultural and Food Chemistry","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Egg Farmers of Canada; Alberta Agriculture and Forestry","keywords":"Chemistry; Angiotensin-converting enzyme 2; Pharmacology; Renin–angiotensin system; Receptor; Downregulation and upregulation; In silico; Enzyme; Peptide; Biochemistry; Blood pressure; Internal medicine; Medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000507866,0.0003498072,0.001192263,0.00008032345,0.00007483908,0.00003246805,0.000319414,0.0004749962,0.00001176611],"category_scores_gemma":[0.0005234936,0.0002312942,0.0007314325,0.0003787921,0.0001607118,0.00001190268,0.0002160146,0.0007962486,8.513077e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007132354,"about_ca_system_score_gemma":0.0001868291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001323918,"about_ca_topic_score_gemma":0.000003062508,"domain_scores_codex":[0.997774,0.0001107827,0.0009956177,0.0004001621,0.0004284248,0.0002909821],"domain_scores_gemma":[0.9971654,0.0001186017,0.001689574,0.000190021,0.0006765058,0.0001598401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001274136,0.0001263436,0.000004714695,0.003007794,0.0006791832,0.000005314276,0.00005527032,0.000004494784,0.9324134,0.000001328384,0.0004965358,0.0630782],"study_design_scores_gemma":[0.0007202434,0.002071977,0.0002333188,0.009965484,0.000373376,0.000725248,0.0005144693,0.000002258655,0.8209847,0.000005905938,0.1639557,0.000447285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3569118,0.6423663,0.000008166233,0.00007866559,0.00004467682,0.000242979,0.00006692663,0.000004970632,0.0002754545],"genre_scores_gemma":[0.2287098,0.7685682,0.0007713411,0.00001528887,0.001285704,0.00001374696,0.00009460336,0.00003935516,0.000501987],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1634592,"threshold_uncertainty_score":0.9431903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07091080120205878,"score_gpt":0.3254009367116847,"score_spread":0.254490135509626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}