{"id":"W3107682875","doi":"10.1021/acs.jafc.0c05544","title":"A Novel Angiotensin Converting Enzyme 2 (ACE2) Activating Peptide: A Reflection of 10 Years of Research on a Small Peptide Ile-Arg-Trp (IRW)","year":2020,"lang":"en","type":"review","venue":"Journal of Agricultural and Food Chemistry","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Egg Farmers of Canada; Alberta Agriculture and Forestry","keywords":"Chemistry; Angiotensin-converting enzyme 2; Pharmacology; Renin–angiotensin system; Receptor; Downregulation and upregulation; In silico; Enzyme; Peptide; Biochemistry; Blood pressure; Internal medicine; Medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007140471,0.0008974198,0.00113688,0.001607269,0.0002352845,0.0009951309,0.0006788148,0.001021843,0.001728002],"category_scores_gemma":[0.0006712583,0.0003163093,0.0004202378,0.001495858,0.0006487005,0.001679948,0.0005605569,0.002957907,0.001412588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006197583,"about_ca_system_score_gemma":0.000889823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007265045,"about_ca_topic_score_gemma":0.00134337,"domain_scores_codex":[0.9998345,0.00002109561,0.00002204737,0.00004642275,0.00005587154,0.0000199748],"domain_scores_gemma":[0.9996684,0.0001345266,0.00004108146,0.00001023464,0.00009918839,0.00004666381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002124937,0.0001644862,0.0003113225,0.01243974,0.0001204667,0.0005657376,0.00007103571,0.0005484088,0.01286984,0.006542203,0.02512605,0.9410281],"study_design_scores_gemma":[0.00003841839,0.0003170716,0.0009470919,0.001029753,0.0001125415,0.002136869,0.00005126351,0.0001959947,0.003536381,0.001906578,0.9896957,0.00003225775],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003490754,0.9976808,0.0004206241,0.0003325234,0.00034817,0.000005724055,0.00002233429,0.000009058296,0.0008317459],"genre_scores_gemma":[0.002085238,0.9951683,0.00067793,0.0004712105,0.0003247558,0.00001173381,0.00006385491,0.000003630016,0.001193338],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001728002,"threshold_uncertainty_score":0.005780756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07091080120205878,"score_gpt":0.3254009367116847,"score_spread":0.254490135509626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}