{"id":"W3107714852","doi":"10.1038/s41436-020-01029-1","title":"Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report","year":2020,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"European Regional Development Fund; Medical Research Council; National Institutes of Health; Centro de Investigación Biomédica en Red de Cáncer; Ministerio de Economía y Competitividad; Deutsche Krebshilfe; Emil Aaltosen Säätiö; Jane ja Aatos Erkon Säätiö; Instrumentariumin Tiedesäätiö; National Institute for Health and Care Research; Generalitat de Catalunya; Parc Geneteg Cymru; Health and Care Research Wales; National Cancer Institute; KWF Kankerbestrijding; Suomen Lääketieteen Säätiö; Kreftforeningen","keywords":"Endometrial cancer; Medicine; MSH6; Lynch syndrome; Hysterectomy; Prospective cohort study; PMS2; Gynecology; Uterine cancer; Oophorectomy; Internal medicine; Cancer; Surgery; DNA mismatch repair; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009856625,0.0003939647,0.001158272,0.0003567811,0.00004056652,0.00000911202,0.0001913415,0.0001957067,0.0001394144],"category_scores_gemma":[0.001666384,0.000342056,0.00009155156,0.0009738415,0.0003379443,0.00005502857,0.0002338653,0.000646853,0.000003969172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936537,"about_ca_system_score_gemma":0.0002205808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006911094,"about_ca_topic_score_gemma":0.000145218,"domain_scores_codex":[0.9963633,0.0001977592,0.001284988,0.001044071,0.000604067,0.0005058549],"domain_scores_gemma":[0.9981459,0.000230104,0.0004033263,0.0007419811,0.000164112,0.0003145452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005128229,0.0001559389,0.8695428,0.0008772364,0.0001261588,0.002738376,0.006814307,0.0001182853,0.1179284,0.000003232666,0.0001305661,0.001051893],"study_design_scores_gemma":[0.006299288,0.002950728,0.9644701,0.001993289,0.0002572886,0.002523609,0.0009078583,0.004165039,0.01575767,0.0001317367,0.0001396609,0.0004036655],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922237,0.004794306,0.0001487858,0.0006162627,0.0003737202,0.001444212,0.00004350551,0.0000745564,0.0002809545],"genre_scores_gemma":[0.9877706,0.0008975368,0.01056708,0.0003173954,0.0002023234,0.0000948411,0.00004817739,0.00006753746,0.00003447005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1021708,"threshold_uncertainty_score":0.9999031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02801373452607438,"score_gpt":0.2931152708120297,"score_spread":0.2651015362859553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}