{"id":"W3107714852","doi":"10.1038/s41436-020-01029-1","title":"Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report","year":2020,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"European Regional Development Fund; Medical Research Council; National Institutes of Health; Centro de Investigación Biomédica en Red de Cáncer; Ministerio de Economía y Competitividad; Deutsche Krebshilfe; Emil Aaltosen Säätiö; Jane ja Aatos Erkon Säätiö; Instrumentariumin Tiedesäätiö; National Institute for Health and Care Research; Generalitat de Catalunya; Parc Geneteg Cymru; Health and Care Research Wales; National Cancer Institute; KWF Kankerbestrijding; Suomen Lääketieteen Säätiö; Kreftforeningen","keywords":"Endometrial cancer; Medicine; MSH6; Lynch syndrome; Hysterectomy; Prospective cohort study; PMS2; Gynecology; Uterine cancer; Oophorectomy; Internal medicine; Cancer; Surgery; DNA mismatch repair; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007814093,0.0001679495,0.0002600067,0.0006951241,0.0002043839,0.0004138568,0.0002579835,0.0002864701,0.001169144],"category_scores_gemma":[0.003392443,0.0001767613,0.0006305691,0.001007736,0.0001002684,0.0002060487,0.0003268518,0.0002810264,0.0001196248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002629714,"about_ca_system_score_gemma":0.000407086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01012973,"about_ca_topic_score_gemma":0.01367322,"domain_scores_codex":[0.9992883,0.0002088917,0.0001106867,0.0001891935,0.0001433258,0.00005971018],"domain_scores_gemma":[0.9980209,0.0005403926,0.0009852694,0.0001658251,0.0001150188,0.0001725998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002750696,0.00001913483,0.9965767,0.00003085646,0.0001638847,0.00006338759,0.00001058186,0.00005855303,0.0001423747,0.00001519974,0.0002473743,0.002396962],"study_design_scores_gemma":[0.00005458984,0.0001027062,0.9984283,0.00001553102,0.0002614157,0.0003904623,0.00004477263,0.0002139689,0.0001091836,0.00001794844,0.0003573581,0.000003858058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911405,0.001188181,0.0001164929,0.0001323297,0.000008007137,0.00001863054,0.006871625,0.000007102812,0.0005170926],"genre_scores_gemma":[0.9938728,0.0005792676,0.0002755662,0.00008513911,0.00001209324,0.00001956614,0.005028266,0.000003172422,0.0001241154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01012973,"threshold_uncertainty_score":0.02014154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02801373452607438,"score_gpt":0.2931152708120297,"score_spread":0.2651015362859553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}