{"id":"W3107760758","doi":"10.1002/biot.202000021","title":"Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform","year":2020,"lang":"en","type":"review","venue":"Biotechnology Journal","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Bioprocess; Computational biology; Vector (molecular biology); Biotechnology; Viral vector; Biology; Baculoviridae; Computer science; Recombinant DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009119966,0.0007643863,0.0006920446,0.0005472447,0.0001961524,0.0009459123,0.000466695,0.0004930386,0.0005339205],"category_scores_gemma":[0.0003893185,0.0003894899,0.0005602463,0.0006627736,0.0003039177,0.0006184201,0.000304932,0.001270388,0.0007891092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005902579,"about_ca_system_score_gemma":0.0005396118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004847356,"about_ca_topic_score_gemma":0.0005370651,"domain_scores_codex":[0.999568,0.00006754087,0.00007051697,0.00009811856,0.0001658783,0.00002982504],"domain_scores_gemma":[0.9998587,0.00003269201,0.00004296014,0.00001555925,0.00003895037,0.00001111888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005808139,0.00005994202,0.0003290599,0.00224948,0.00004411458,0.0001505312,0.0001073952,0.00184621,0.9219646,0.004526085,0.0005977119,0.06806682],"study_design_scores_gemma":[0.0000283191,0.0006026157,0.001766791,0.0002325571,0.0001539413,0.0008495589,0.00005042325,0.00391061,0.7910315,0.001823891,0.1994735,0.0000763118],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2105132,0.4654369,0.2984333,0.00146432,0.0008798511,0.0008194376,0.001406834,0.001177056,0.01986911],"genre_scores_gemma":[0.2871907,0.4225439,0.2784747,0.0006561519,0.0002458595,0.0006524771,0.002701123,0.0002402505,0.007294958],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0009459123,"threshold_uncertainty_score":0.004823148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148941551362571,"score_gpt":0.2973592721228177,"score_spread":0.2558698566091919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}