{"id":"W3107760758","doi":"10.1002/biot.202000021","title":"Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform","year":2020,"lang":"en","type":"review","venue":"Biotechnology Journal","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Bioprocess; Computational biology; Vector (molecular biology); Biotechnology; Viral vector; Biology; Baculoviridae; Computer science; Recombinant DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003305349,0.0004609241,0.0008790992,0.0002931011,0.0002668342,0.00005013404,0.0004973073,0.001139659,0.000009699955],"category_scores_gemma":[0.0001620281,0.0003259075,0.0002954278,0.0004138247,0.0002082686,0.0000149453,0.000425096,0.0008574226,0.000001463772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001153132,"about_ca_system_score_gemma":0.0004139916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001890212,"about_ca_topic_score_gemma":0.000003650792,"domain_scores_codex":[0.9977695,0.0002935699,0.0008143576,0.000513743,0.0002008503,0.0004080318],"domain_scores_gemma":[0.9983611,0.00003560639,0.001074787,0.0003319089,0.00008011093,0.0001164927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001011492,0.00022804,0.00002892023,0.0007518301,0.0002109316,0.0001383799,0.0000315816,0.0001379317,0.8649032,0.000002672782,0.0002124244,0.133253],"study_design_scores_gemma":[0.001903866,0.001441035,0.00001183475,0.007764404,0.0006944806,0.0009560437,0.0001208195,0.0002263673,0.812814,0.0002366242,0.1727678,0.001062696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06943823,0.9255123,0.004151403,0.0000166003,0.0003978187,0.0004399094,0.00002218083,0.00001661787,0.000004960024],"genre_scores_gemma":[0.01655486,0.9813212,0.001870119,0.00004973472,0.00007370105,0.00002434881,0.00003150172,0.00006527896,0.000009274752],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1725554,"threshold_uncertainty_score":0.9999193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148941551362571,"score_gpt":0.2973592721228177,"score_spread":0.2558698566091919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}