{"id":"W3107797793","doi":"10.15252/embr.202050640","title":"The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity","year":2020,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; University of Toronto; PROTEO; Université de Sherbrooke","funders":"Common Fund; National Institute of Neurological Disorders and Stroke; National Cancer Institute; NIH Office of the Director; National Human Genome Research Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institute of Mental Health; ALS Society of Canada; Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Motor Neurone Disease Association; Francis Crick Institute; Canada Research Chairs; National Institutes of Health; Government of Canada","keywords":"Gene; Biology; Genetics; Toxicity; Computational biology; Cell biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267912,0.0006123955,0.0002542153,0.0004943907,0.0002639926,0.0002810125,0.0002274045,0.0003877161,0.001432899],"category_scores_gemma":[0.000144342,0.0001393892,0.0004961062,0.0004082639,0.0004883633,0.0002060023,0.0004024789,0.0004058615,0.0007018292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005429938,"about_ca_system_score_gemma":0.0003207661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004032808,"about_ca_topic_score_gemma":0.0005170972,"domain_scores_codex":[0.9998631,0.00001542706,0.00001491869,0.00004052329,0.000041303,0.00002457252],"domain_scores_gemma":[0.999886,0.00002158202,0.00003957615,0.00000985163,0.00001426566,0.00002864483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001040441,0.0000117262,0.0008079434,0.00005417291,0.000007260645,0.0006138171,0.0000320126,0.0001001182,0.9904145,0.000933441,0.0001712598,0.006749773],"study_design_scores_gemma":[0.00004868052,0.0004767441,0.02102364,0.00004698789,0.0001018999,0.01039426,0.0001445086,0.002391141,0.9136447,0.001067129,0.05061502,0.00004523541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623356,0.003520629,0.02543609,0.0003397246,0.0001779844,0.00009344565,0.002222734,0.0005686452,0.005305188],"genre_scores_gemma":[0.9821202,0.0007524185,0.009514564,0.0001279439,0.00004026912,0.00004308401,0.003303134,0.00004406241,0.004054266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432899,"threshold_uncertainty_score":0.004793525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298831258277827,"score_gpt":0.2811796123553477,"score_spread":0.251296486527565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}