{"id":"W3107797793","doi":"10.15252/embr.202050640","title":"The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity","year":2020,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; University of Toronto; PROTEO; Université de Sherbrooke","funders":"Common Fund; National Institute of Neurological Disorders and Stroke; National Cancer Institute; NIH Office of the Director; National Human Genome Research Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institute of Mental Health; ALS Society of Canada; Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Motor Neurone Disease Association; Francis Crick Institute; Canada Research Chairs; National Institutes of Health; Government of Canada","keywords":"Gene; Biology; Genetics; Toxicity; Computational biology; Cell biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008375869,0.0002113618,0.0003944959,0.00003923203,0.000419503,0.0000968718,0.0001005805,0.00009616429,0.0002412248],"category_scores_gemma":[0.001487695,0.0001238795,0.00008205089,0.0005189172,0.00008804672,0.00007682285,0.0002301848,0.0004222255,0.00006243644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001642366,"about_ca_system_score_gemma":0.000268046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001505833,"about_ca_topic_score_gemma":0.00002229176,"domain_scores_codex":[0.9970532,0.0000745553,0.0005360033,0.0005414844,0.0009548272,0.0008399531],"domain_scores_gemma":[0.998255,0.0001072776,0.0002176317,0.0005224587,0.000255362,0.0006423278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001739692,0.0002633705,0.1311874,0.0002103647,0.0006152957,0.02516707,0.005027825,0.00007341224,0.806154,0.00006156641,0.02027662,0.009223438],"study_design_scores_gemma":[0.004541107,0.004212854,0.4717832,0.0007935154,0.0002306068,0.004444631,0.0005908791,0.003261617,0.4182151,0.0001326963,0.09057724,0.001216513],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630278,0.0001262727,0.0006069562,0.03263667,0.00008390861,0.001726978,0.00001055852,0.0001552303,0.001625666],"genre_scores_gemma":[0.9939841,0.00002545116,0.0006274536,0.003838041,0.0004588724,0.0001103008,0.00002221595,0.000043993,0.0008895561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3879388,"threshold_uncertainty_score":0.5051659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298831258277827,"score_gpt":0.2811796123553477,"score_spread":0.251296486527565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}