{"id":"W3107924035","doi":"10.1016/j.omtm.2020.11.014","title":"CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Gilead Sciences","keywords":"cccDNA; Virology; Hepatitis B virus; Cas9; Entecavir; Biology; Adeno-associated virus; Genetic enhancement; Virus; Genome editing; CRISPR; Plasmid; Gene; Recombinant DNA; Vector (molecular biology); Genetics; Lamivudine; HBsAg","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004281036,0.0002686898,0.0002822159,0.0003378836,0.0002151834,0.0004292559,0.0003018058,0.0005240753,0.004781781],"category_scores_gemma":[0.0002141328,0.0002529834,0.0002998773,0.0001594827,0.0004077124,0.0002502373,0.0002247914,0.0009440779,0.0005832866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178739,"about_ca_system_score_gemma":0.0004225588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007517826,"about_ca_topic_score_gemma":0.001097774,"domain_scores_codex":[0.999773,0.00005976319,0.00002452311,0.0000542792,0.00005390973,0.00003459834],"domain_scores_gemma":[0.9998665,0.00002582151,0.00003726473,0.00002824561,0.000008485799,0.00003360727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003641179,0.00007203694,0.0002907544,0.00007596031,0.00002554649,0.0001660246,0.00003648246,0.0002158574,0.9893101,0.001509595,0.0006070711,0.007326395],"study_design_scores_gemma":[0.0001376923,0.000679793,0.002256976,0.00003474896,0.00005215621,0.001785673,0.00003608045,0.003114702,0.9721603,0.0006480681,0.01907369,0.00002013192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.879767,0.004614014,0.096653,0.001496662,0.0005075182,0.000307902,0.003594693,0.001810779,0.01124852],"genre_scores_gemma":[0.9637307,0.001798938,0.01976976,0.0002204996,0.00002356142,0.0001489311,0.001234348,0.0001494675,0.01292382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004781781,"threshold_uncertainty_score":0.01599663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04722707968031607,"score_gpt":0.4325836836005674,"score_spread":0.3853566039202513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}