{"id":"W3107924035","doi":"10.1016/j.omtm.2020.11.014","title":"CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Gilead Sciences","keywords":"cccDNA; Virology; Hepatitis B virus; Cas9; Entecavir; Biology; Adeno-associated virus; Genetic enhancement; Virus; Genome editing; CRISPR; Plasmid; Gene; Recombinant DNA; Vector (molecular biology); Genetics; Lamivudine; HBsAg","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001441937,0.0002889531,0.0005480884,0.00005687249,0.00004265638,0.00001831533,0.0003493361,0.0002875541,0.00006045336],"category_scores_gemma":[0.0009309658,0.0002943535,0.0002257757,0.0002509654,0.00008147434,0.00000384333,0.0002131795,0.0002952773,0.0000081006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002593216,"about_ca_system_score_gemma":0.0002163707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004389351,"about_ca_topic_score_gemma":0.00004670261,"domain_scores_codex":[0.996928,0.000628766,0.001211866,0.0006342672,0.0002245509,0.0003724913],"domain_scores_gemma":[0.9989958,0.0001278688,0.000205793,0.0003366171,0.0001340602,0.0001998727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000144215,0.0001367448,0.004013046,0.00002831407,0.0001682297,0.00002028358,0.0001855623,0.0002407348,0.9132506,0.00001175733,0.00005616049,0.08174434],"study_design_scores_gemma":[0.001895918,0.000398884,0.02928841,0.00002723486,0.00001434907,0.000003332509,0.00001234844,0.000360923,0.9439744,0.00003559021,0.02366645,0.0003221758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5973251,0.001859042,0.4001458,0.0001514918,0.0001724987,0.0002453473,0.000003691609,0.00001995036,0.00007704035],"genre_scores_gemma":[0.5365747,0.001981919,0.4594911,0.001562842,0.0002078661,0.00004330234,0.00006699453,0.00005553865,0.00001577282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08142217,"threshold_uncertainty_score":0.9999509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04722707968031607,"score_gpt":0.4325836836005674,"score_spread":0.3853566039202513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}