{"id":"W3107924164","doi":"","title":"DNA Demethylase transforms normal cells into highly invasive and metastatic cancer cells: Identification and characterization of novel metastatic cancer targets, therapeutic intervention for these targets, and signaling pathways leading to DNA demethylation","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cancer research; DNA methylation; Biology; Demethylating agent; Ectopic expression; DNA demethylation; Carcinogenesis; Cell culture; Cancer; Cancer cell; Gene knockdown; Metastasis; Molecular biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000178263,0.0003280969,0.0002175025,0.0002883009,0.0001412499,0.0002678483,0.0002141103,0.0002345308,0.00148007],"category_scores_gemma":[0.00008562292,0.0001745818,0.0002216468,0.0002133378,0.0002237961,0.000128329,0.0001480626,0.0005270296,0.0004659744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003751433,"about_ca_system_score_gemma":0.0002181281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009389736,"about_ca_topic_score_gemma":0.001905867,"domain_scores_codex":[0.99988,0.00001141598,0.00001157882,0.00002636528,0.00005278985,0.00001792354],"domain_scores_gemma":[0.9999329,0.0000128303,0.00001383671,0.000009763534,0.000008926745,0.00002171247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001478366,0.000008259983,0.00007980873,0.00001066589,0.000002094564,0.00001222237,0.000003317451,0.000009959945,0.9995044,0.00002540166,0.00001282921,0.0003161766],"study_design_scores_gemma":[0.000006971722,0.00009610647,0.00205557,0.000002109896,0.000006640598,0.0001452009,0.000008187409,0.0003760206,0.9959289,0.0000170113,0.001355525,0.000001652331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793956,0.003475397,0.01271606,0.0002053724,0.00004060013,0.0001406448,0.001538453,0.0001928852,0.002294856],"genre_scores_gemma":[0.9757181,0.002570085,0.01159188,0.00007809511,0.00001035056,0.0001112364,0.003695769,0.0000411621,0.006183184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148007,"threshold_uncertainty_score":0.004951358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0787249978234601,"score_gpt":0.3578166929723356,"score_spread":0.2790916951488756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}