{"id":"W3107972000","doi":"10.1128/mbio.01821-20","title":"Phagosomal F-Actin Retention by Cryptococcus gattii Induces Dendritic Cell Immunoparalysis","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Government of Canada; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Phagosome; Cryptococcus gattii; Biology; Immune system; Microbiology; Dendritic cell; Cell biology; Macrophage; Cryptococcosis; Cryptococcus neoformans; Phagocytosis; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004808051,0.0001150907,0.000227034,0.00002671064,0.0001439834,0.00002708982,0.00004392146,0.00006249633,0.0004323411],"category_scores_gemma":[0.00005553183,0.0001007668,0.0001150886,0.0002317724,0.00004353771,0.00007219812,0.00003527653,0.0001788426,0.0003152082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003414639,"about_ca_system_score_gemma":0.00001494456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001045079,"about_ca_topic_score_gemma":0.000003368447,"domain_scores_codex":[0.9992683,0.00002792439,0.0001881817,0.0002091181,0.0001308767,0.0001756046],"domain_scores_gemma":[0.9996449,0.0000259042,0.00004900568,0.0001257034,0.00005906938,0.00009539716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008461879,0.0002044749,0.01105937,0.000105454,0.0001376534,0.00002737171,0.0004742901,0.000001466583,0.9505823,0.00002423771,0.03515878,0.002139951],"study_design_scores_gemma":[0.003696953,0.002015596,0.04434718,0.0001175603,0.00078455,0.00004141226,0.001905309,0.0003504572,0.8354817,0.00005918674,0.1106387,0.0005614367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867786,0.001534748,0.0001024376,0.00274964,0.0001820021,0.000202592,0.00001237823,0.00009690801,0.008340728],"genre_scores_gemma":[0.997609,0.00009953934,0.0001796435,0.0006363523,0.0001546682,0.00003374304,0.00003297027,0.00001352929,0.001240609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1151007,"threshold_uncertainty_score":0.4733832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936697324262814,"score_gpt":0.2579868675279582,"score_spread":0.2286198942853301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}