{"id":"W3107972000","doi":"10.1128/mbio.01821-20","title":"Phagosomal F-Actin Retention by Cryptococcus gattii Induces Dendritic Cell Immunoparalysis","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Government of Canada; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Phagosome; Cryptococcus gattii; Biology; Immune system; Microbiology; Dendritic cell; Cell biology; Macrophage; Cryptococcosis; Cryptococcus neoformans; Phagocytosis; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007989373,0.0001629322,0.0001251853,0.000100479,0.0001264476,0.0001638441,0.00007378936,0.0002286072,0.0008956353],"category_scores_gemma":[0.00008304849,0.00006504844,0.0001187197,0.00006549267,0.0001518883,0.00008755425,0.0001846685,0.0003847862,0.0002123882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038131,"about_ca_system_score_gemma":0.000176837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004482449,"about_ca_topic_score_gemma":0.0006177515,"domain_scores_codex":[0.9999133,0.00001457176,0.000005340649,0.0000129617,0.00001304664,0.00004074116],"domain_scores_gemma":[0.9999403,0.00001089377,0.00001300439,0.000006962075,0.000006168856,0.00002265642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002649546,0.00005331194,0.0003497632,0.00003523187,0.000001959049,0.0001748588,0.00001463235,0.00002028743,0.9977487,0.00005535862,0.00005377708,0.00122717],"study_design_scores_gemma":[0.0000768105,0.001210625,0.0254194,0.00002099979,0.00001351849,0.001137107,0.0001162362,0.001112445,0.9677505,0.00009442476,0.003042604,0.000005188659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979273,0.0004971776,0.0002828559,0.00006953511,0.00002005715,0.00001585565,0.00005096806,0.00001617519,0.001119974],"genre_scores_gemma":[0.9985934,0.0002327967,0.0003050288,0.00004841308,0.000008822674,0.000009776041,0.00007046769,0.000002877274,0.0007284214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008956353,"threshold_uncertainty_score":0.002996266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936697324262814,"score_gpt":0.2579868675279582,"score_spread":0.2286198942853301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}